摘要
本文以化合物1-(4-(叔丁基)苯基)-3-羟基-2-甲基吡啶-4(1H)-酮(以下简称为HAINU-19)为有效成分,制备微乳剂并测定其杀菌活性。首先,通过对溶剂、助溶剂、乳化剂的筛选,确定2.5%HAINU-19微乳剂配方(质量分数)为:2.5%HAINU-19、15%乙醇、10%环己酮、20%乳化剂(宁乳1601#:农乳500#:AC-1810=3:3:1),蒸馏水补足100%。各项指标均符合国家标准。盆栽药效试验结果表明,2.5%HAINU-19微乳剂在稀释1000、500和250倍剂量下,对小麦条锈病的保护性防治效果均为100%,治疗性防治效果分别为76.67%、81.00%和82.33%。田间药效试验结果表明,2.5%HAINU-19微乳剂对水稻纹枯病的防治效果100倍稀释液为86.13%,200倍稀释液为71.24%。该研究可为杀菌化合物HAINU-19的开发应用提供试验依据和技术支持。
In this study,the compound 1-(4-(tert-butyl)phenyl)-3-hydroxy-2-methylpyridine-4(1H)-one(hereinafter referred to as HAINU-19)was used as the active ingredient to prepare the microe-mulsion and determine its antifungal activity.First,through the screening solvents,co-solvents,and transparent,the formulation of 2.5%HAINU-19 microemulsion(mass fraction)was determined as follows:2.5%HAINU-19,15%ethanol,10%cyclohexanone,20%transparent(1601#:500#:AC-1810=3:3:1),with distilled water making up to 100%.All indicators meet national standards.The bioassay result of pot experiments showed that the protective and curative effects of 2.5%HAINU-19 microemulsion on wheat stripe rust were 100%at 1000,500,and 250-fold dilutions,and curative effects were 76.67%,81.00%,and 82.33%,respectively.The field trial results showed that the 2.5%HAINU-19 microemulsion had a control efficacy of 86.13%on rice sheath blight at a 100-fold dilution and 71.24%at a 200-fold dilution.This study can provide an experimental basis and technical support for the development and application of the antifungal compound HAINU-19.
作者
赵静杰
余海涛
张勃
赵延存
尹丰满
张羲
孙然锋
ZHAO Jingjie;YU Haitao;ZHANG Bo;ZHAO Yancun;YIN Fengman;ZHANG Xi;SUN Ranfeng(Key Laboratory of Green Prevention and Control of Tropical Plant Diseases and Pest,Ministry of Education,School of Tropical Agriculture and Forestry,Hainan University,Haikou 570228,China;Institute of Plant Protection,Gansu Academy of Agricultural Sciences,Lanzhou 730070,China;Institute of Plant Protection,Jiangsu Academy of Agricultural Sciences,Nanjing 210014,China)
出处
《农药学学报》
CAS
CSCD
北大核心
2024年第4期735-743,共9页
Chinese Journal of Pesticide Science
基金
国家自然科学基金(22067004)
海南省自然科学基金资助(321CXTD436).
