摘要
隐丹参酮是从丹参Salvia miltiorrhiza中分离得到的具有抗肿瘤、神经保护、抗菌、抗炎等生物活性的脂溶性化学成分,但由于其难溶于水、口服生物利用度低等缺点,限制了其药效发挥及临床应用。采用新型制剂技术可以有效改善隐丹参酮的溶解度和生物利用度,并且还可以增强药物稳定性、实现靶向应答及缓控释药物的效果,具有良好的应用前景。通过对隐丹参酮的药理作用及新型制剂技术进行综述,为隐丹参酮的临床应用和新药研发提供研究依据。
Cryptotanshinone(CTS),a lipophilic chemical compound isolated from Danshen(Salvia miltiorrhiza),exhibits biological activities such as antitumor,neuroprotection,antibacterial,and anti-inflammatory properties.However,its poor solubility in water and low oral bioavailability hinder its efficacy and clinical application.The use of novel preparation technologies can effectively enhance the solubility and bioavailability of CTS,and also improve drug stability,enable targeted responses,and achieve controlled drug release,presenting promising application prospects.A review of the pharmacological effects of CTS and the novel preparation technologies provides a research basis for the clinical application of CTS and the development of new drugs.
作者
李佳莉
张利
辛佳芸
高苑
侯泉杰
徐希科
冯玉
祖先鹏
LI Jiali;ZHANG Li;XIN Jiayun;GAO Yuan;HOU Quanjie;XU Xike;FENG Yu;ZU Xianpeng(School of Pharmacy,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;School of Pharmacy,Naval Medical University,Shanghai 200433,China)
出处
《中草药》
CAS
CSCD
北大核心
2024年第14期4930-4938,共9页
Chinese Traditional and Herbal Drugs
基金
上海市卫生健康委员会中医药科研项目(2024QN057)
国家重点研发计划(2022YFC3502000)
军队后勤科研项目(BHJ22J020)
海军军医大学“深蓝”工程启航人才计划基金。
关键词
隐丹参酮
抗肿瘤
自噬
新型制剂技术
纳米粒
水凝胶
cryptotanshinone
antitumor
autophagy
novel preparation technology
nanoparticles
hydrogels
