摘要
糖基化作为蛋白质重要的翻译后修饰,在乙型肝炎病毒(hepatitis B,HBV)识别肝细胞受体、肝细胞内复制、分泌和免疫逃逸等过程中起着重要的作用。研究HBV相关的糖基化修饰,不仅可以揭示HBV与宿主细胞的相互作用机制,也为HBV感染的治疗和干预提供了新的视角。本文总结了HBV感染过程中糖基化作用、相关功能及应用等研究进展。
Glycosylation,as an important post translational modification of proteins,plays an important role in hepatitis B virus(HBV)signal recognition,intra-hepatocyte replication,secretion and immune escape.Investigating HBV-related glycosylation not only reveals the interaction mechanism between HBV and host cells,but also provides a new perspective for the treatment and intervention of HBV infection.This review summarized the progress of glycosylation,related functions,and potential applications in the process of HBV infection.
作者
刘学恩
张超
张平博
徐蕾
吴茜
陈萃英
庄辉
LIU Xueen;ZHANG Chao;ZHANG Pingbo;XU Lei;WU Qian;CHEN Cuiying;ZHUANGHui(Department of Microbiology&Center of Infectious Diseases,School of BasicMedical Sciences,Peking University Health Science Center,Beijing 100191;不详)
出处
《中国病毒病杂志》
CAS
2024年第3期218-224,共7页
Chinese Journal of Viral Diseases
关键词
乙型肝炎病毒
糖基化
临床价值
Hepatitis B virus
Glycosylation
Clinical value
