摘要
心力衰竭是严重影响全球生命健康的疾病之一,其病理发生发展过程与炎症浸润、能量代谢紊乱和线粒体功能障碍密切相关。Hippo-YAP通路具有感知机械压力刺激,从而调控细胞增殖、分化和器官大小的生物学功能。运动作为一种简单易行且无副作用的非药物治疗手段,在调控免疫炎症反应和线粒体质量控制等方面发挥重要作用,有效抑制心力衰竭病理发展;研究发现,运动可能通过调节Hippo-YAP通路来改善心力衰竭。该文综述了Hippo-YAP通路与心力衰竭发生发展的生物学机制,进一步论述了运动调节Hippo-YAP通路改善心力衰竭的分子机制,以期为预防和治疗心力衰竭提供新思路和理论依据。
Heart failure is one of the most important diseases affecting global life and health.Its pathogenesis is closely related to the disorder of inflammatory infiltration,energy metabolism and mitochondrial function.The Hippo-YAP pathway has the biological function of sensing mechanical pressure to regulate cell proliferation and differentiation and organ size.Exercise,as a simple and easy non-pharmacological treatment without side effects,plays an important role in modulating immune-inflammatory responses and mitochondrial quality control,and effectively inhibits the development of heart failure pathology.It has been found that exercise may ameliorate heart failure by modulating the Hippo-YAP pathway.This paper reviews the biological mechanism of the Hippo-YAP pathway and the development of heart failure,and further discusses the molecular mechanism by which exercise regulates the Hippo-YAP pathway to improve heart failure,in order to provide new ideas and theoretical basis for the prevention and treatment of heart failure.
作者
鞠文宇
陈志欣
张嘉敏
王友华
JU Wen-Yu;CHEN Zhi-Xin;ZHANG Jia-Min;WANG You-Hua(School of Physical Education,Shaanxi Normal University,Xi’an 710119,China)
出处
《生命科学》
CSCD
2024年第6期797-806,共10页
Chinese Bulletin of Life Sciences
基金
国家自然科学基金项目(81570449)
2023年大学生创新创业项目(S202310718159,S202310718175,S202310718195)
陕西师范大学青年学者培育项目(2022-BA001)。
