摘要
肝再生磷酸酶2(phosphatase of regenerating liver 2,PRL2)属于肝再生磷酸酶家族,在人体各个组织器官中广泛表达。PRL2异常高表达与肿瘤的发生发展和临床预后密切相关,是多种癌症的潜在治疗靶点。研究表明PRL2通过两种机制发挥促癌作用:一是依赖假磷酸酶活性,主要与镁离子转运体CNNM3结合;二是凭借磷酸酶活性,使底物分子PTEN等去磷酸化。因此,阻断PRL2与CNNM3结合或抑制PRL2磷酸酶活性有望成为新的抗癌策略。现综述了PRL2与不同癌症的联系、其促癌分子机制和抑制剂的最新研究进展。
The phosphatase of regenerating liver 2(PRL2),a member of the phosphatases of regenerating liver,exhibits widespread expression throughout various tissues and organs in the human body.Elevated expression of PRL2 is closely associated with the initiation,progression,and clinical outcomes of tumors,rendering it a prospective therapeutic target across various malignancies.Studies indicate that PRL2 functions in cancer progression through two mechanisms:firstly,it leverages pseudophosphatase activity,which mainly interacts with the magnesium ion transporter CNNM3;the second is to utilize phosphatase activity to dephosphorylate substrate molecules such as PTEN.Consequently,strategies aimed at disrupting the interaction between PRL2 and CNNM3 or inhibting the phosphatase activity of PRL2 represent novel avenues for anticancer intervention.This review comprehensively outlines the associations between PRL2 with diverse cancers,elucidating the molecular mechanisms underlying its oncogenic properties and the latest advancements of its inhibitors.
作者
李茹薇
陶浩强
肖奕菲
王佳银
于洁
LI Ru-Wei;TAO Hao-Qiang;XIAO Yi-Fei;WANG Jia-Yin;YU Jie(Savaid Stomatology School of Hangzhou Medical College,Hangzhou 310013,China;School of Laboratory Medicine and Bioengineering,Hangzhou Medical College,Zhejiang Provincial Key Laboratory of Neuropsychiatric Drug Research,Hangzhou 310013,China)
出处
《生命科学》
CSCD
2024年第6期771-776,共6页
Chinese Bulletin of Life Sciences
基金
浙江省自然科学基金项目(LQ21H310006)
浙江省医药卫生科技计划项目(2024KY921)
浙江省教育厅高校一般科研项目(Y202352851)
国家级大学生创新创业训练计划项目(202313023012)。
