摘要
急性胰腺炎是一种与炎性反应密切相关的消化系统疾病。NOD样受体蛋白3(NLRP3)炎性小体是一种蛋白质复合物,在炎症风暴发生、炎性状态的调节中起着至关重要的作用,其通过激活氧化应激、调节肠道菌群和驱动细胞焦亡等,影响急性胰腺炎的发生、发展和结局转归,有望成为急性胰腺炎诊断的生物标志物及治疗新靶点。现就NLRP3炎性小体与急性胰腺炎的关系以及其相互影响机制的研究现状作一综述。
Acute pancreatitis(AP)is a gastrointestinal disease closely associated with inflammatory response.The NLRP3 inflammasome is a protein complex,which plays a crucial role in the development of inflammatory storms and the regulation of inflammatory states.NLRP3 inflammasome affects the occurrence,development and outcome of AP by activating oxidative stress,regulating intestinal flora and driving cellular pyroptosis,and it is expected to become a biomarker and therapeutic target for the diagnosis of AP.The current state of research on the relationship between NLRP3 inflammasome and AP and the mechanism of their interaction are summarized.
作者
李嘉兴
孙乙文
李文星
Li Jiaxing;Sun Yiwen;Li Wenxing(Department of General Surgery,the Second Hospital of Shanxi Medical University,Taiyuan 030001,China)
出处
《中华普通外科学文献（电子版）》
CAS
2024年第4期300-304,共5页
Chinese Archives of General Surgery(Electronic Edition)
基金
山西省自然科学研究面上项目(20210302123261)。
