摘要
目的分析老年缺血性脑卒中患者颈动脉斑块特征及血液流变学与疾病分型及严重程度的关系。方法选择240例老年缺血性脑卒中患者为观察组,按疾病分型[完全前循环梗死(TACI)、部分前循环梗死(PACI)、后循环梗死(POCI)、腔隙性梗死(LACI)]和病情严重程度(轻度、中度、重度)对观察组患者进行二次分组;另选取60例老年健康体检者为对照组。检测受试者颈动脉斑块特征[颈动脉内膜中层厚度(IMT)、斑块数量、斑块最大长径、斑块性质]、血液流变学[红细胞沉降率(ESR)、红细胞比容(HCT)、血浆纤维蛋白原(Fib)、血浆黏度、全血黏度]指标,分析颈动脉斑块特征及血液流变学与疾病分型及严重程度的关系。结果观察组IMT、斑块数量、斑块最大长径、ESR、HCT、Fib、血浆黏度、全血黏度水平高于对照组,差异有统计学意义(P<0.05);LACI组IMT、斑块数量、斑块最大长径低于TACI、PACI、POCI组,稳定型斑块比率则更高,差异有统计学意义(P<0.05);LACI组ESR、HCT、Fib、血浆黏度、全血黏度水平低于TACI、PACI、POCI组,差异有统计学意义(P<0.05);轻度组IMT、斑块数量、斑块最大长径低于中度组和重度组,稳定型斑块比率高于中度组和重度组,中度组的IMT、斑块数量、斑块最大长径低于重度组,差异均有统计学意义(P<0.05);轻度组ESR、HCT、Fib、血浆黏度、全血黏度水平低于中度组和重度组,中度组上述指标低于重度组,差异有统计学意义(P<0.05)。结论老年缺血性脑卒中患者颈动脉斑块特征及血液流变学与疾病分型及严重程度有关,TACI、PACI、POCI型老年缺血性脑卒中患者的颈动脉斑块状态和血液流变学异常情况较LACI型患者更为严重。
Objective To analyze the relationships of carotid plaque characteristics and hemorheology with disease classification and severity in elderly patients with ischemic stroke.Methods A total of 240 elderly patients with ischemic stroke were selected as observation group,and were further divided into different groups based on disease classification[complete anterior circulation infarction(TACI),partial anterior circulation infarction(PACI),posterior circulation infarction(POCI),lacunar infarction(LACI)]and severity of the disease(mild,moderate,and severe);another 60 elderly healthy individuals with physical examinations were selected as control group.The characteristics of carotid artery plaques[carotid intima-media thickness(IMT),number of plaques,maximum length of plaques,and nature of plaques]as well as hemorheology indexes[erythrocyte sedimentation rate(ESR),hematocrit(HCT),plasma fibrinogen(Fib),plasma viscosity,and whole blood viscosity]were measured in all the cases,and the relationships of carotid plaque characteristics and hemorheology with disease classification and severity were analyzed.Results The IMT,the number of plaques,maximum diameter of plaques,ESR,HCT,Fib,plasma viscosity,and whole blood viscosity in the observation group were significantly higher than those in the control group(P<0.05);the IMT,the number of plaques,and maximum diameter of plaques in the LACI group were significantly lower than those in the TACI,PACI,and POCI groups,while the ratios of stable plaques were significantly higher(P<0.05);the ESR,HCT,Fib,plasma viscosity,and whole blood viscosity in the LACI group were significantly lower than those in the TACI,PACI,and POCI groups(P<0.05);the IMT,the number of plaques,and maximum diameter of plaques in the mild group were significantly lower than those in the moderate and severe groups,the ratio of stable plaques was significantly higher than that in the moderate and severe groups,the IMT,the number of plaques,and maximum diameter of plaques in the moderate group were significantly lo
作者
吴国华
张晓飞
王琦
李超
闫雪芳
WU Guohua;ZHANG Xiaofei;WANG Qi;LI Chao;YAN Xuefang(CT/MRI Room,Handan Central Hospital in Hebei Province,Handan,Hebei,056008;the First Department of Geriatrics,Handan Central Hospital in Hebei Province,Handan,Hebei,056008)
出处
《实用临床医药杂志》
CAS
2024年第13期58-62,共5页
Journal of Clinical Medicine in Practice
基金
河北省医学科学研究课题计划(20231944)。
关键词
缺血性脑卒中
颈动脉斑块
斑块性质
血液流变学
疾病分型
病情程度
ischemic stroke
carotid artery plaque
plaque property
hemorheology
disease classification
severity of the disease
