摘要
目的 探讨柴芍承气汤加味灌肠联合生长抑素对重症急性胰腺炎(severe acute pancreatitis,SAP)的治疗效果。方法 选取2020年5月—2023年5月金昌市人民医院收治的82例SAP患者为研究对象,按随机数表法分为两组,各41例。对照组予以生长抑素治疗,观察组在对照组基础上加用柴芍承气汤加味灌肠治疗,持续7 d。比较两组临床疗效、炎症水平、肠道屏障指标、胃肠功能恢复情况及不良反应。结果 观察组治疗总有效率为95.12%,高于对照组的80.49%,差异有统计学意义(χ^(2)=4.100,P=0.043)。观察组治疗后C反应蛋白、肿瘤坏死因子-α、白细胞介素-6、血清淀粉酶、D-乳酸、二胺氧化酶、内毒素水平低于对照组,差异有统计学意义(P均<0.05)。观察组胃肠功能恢复时间短于对照组,差异有统计学意义(P<0.05)。两组均无明显不良反应。结论 柴芍承气汤加味灌肠联合生长抑素可提高SAP患者疗效,加快炎症消退,减轻肠道屏障损伤,缩短胃肠功能恢复时间,安全可靠。
Objective To investigate the therapeutic effect of Chaishao Chengqi Decoction supplemented enema combined with somatostatin on severe acute pancreatitis(SAP).Methods A total of 82 SAP patients admitted in Jinchang People's Hospital from May 2020 to May 2023 were selected as the research objects and divided into two groups according to the random number table method,with 41 cases in each group.The control group was treated with somatostatin,and the observation group was treated with modified Chaishao Chengqi decoction enema on the basis of the control group for 7 days.The clinical efficacy,inflammatory level,intestinal barrier index,gastrointestinal function recovery and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 95.12%,which was higher than 80.49% in the control group,and the difference was statistically significant(χ^(2)=4.100,P=0.043).After treatment,the levels of C-reactive protein,tumor necrosis factor-α,interleukin-6,blood amylase,the levels of Dlactic acid,diamine oxidase and endotoxin in the observation group were lower than those in the control group,and the differences were statistically significant(all P<0.05).The recovery time of gastrointestinal function in the observation group was shorter than that in the control group,and the difference was statistically significant(P<0.05).There were no obvious adverse reactions in both groups.Conclusion Chaishao Chengqi Decoction supplemented enema combined with somatostatin can improve the curative effect of SAP patients,accelerate the regression of inflammation,reduce intestinal barrier damage,shorten the recovery time of gastrointestinal function,and is safe and reliable.
作者
王治国
许玉晶
郭天平
WANG Zhiguo;XU Yujing;GUO Tianping(Department of Emergency I,Jinchang People's Hospital,Jinchang 737100,Gansu,China;Department of Infectious Diseases,Jinchang Central Hospital,Jinchang 737100,Gansu,China;Department of NephrologyⅢ,Jinchang Central Hospital,Jinchang 737100,Gansu,China)
出处
《世界复合医学》
2024年第4期33-37,共5页
World Journal of Complex Medicine
关键词
重症急性胰腺炎
柴芍承气汤加味灌肠
生长抑素
炎症水平
Severe acute pancreatitis
Chaishao Chengqi Decoction supplemented enema
Somatostatin
Inflammation level
