摘要
目的分析精神分裂症患者应用齐拉西酮、利培酮治疗后其认知功能、γ-氨基丁酸(GABA)、抑制素(INH)、乙酰胆碱(Ach)等变化情况。方法采用随机数字表法将100例于2020年6月至2023年6月,从河北省唐山市第五医院精神科选取的精神分裂症患者分为试验组和对照组,各50例。试验组和对照组分别口服盐酸齐拉西酮片、利培酮片,疗程均为2个月。比较两组疗效(治疗2个月后)、精神症状评分、认知功能、神经递质水平(治疗前和治疗2个月后)及安全性(治疗期间)。结果试验组治疗2个月后总有效率为92.00%,高于对照组的76.00%,差异有统计学意义(χ^(2)=4.762,P<0.05)。两组治疗2个月后较治疗前比较,阳性、阴性、精神病理症状评分及总分和血清INH、Ach水平降低,试验组较对照组更低,差异有统计学意义(t=9.449、5.243、20.206、17.310、15.229、7.345,P<0.05);两组治疗2个月后较治疗前比较,即刻、延迟、视觉、延迟视觉记忆评分及总分和血清GABA水平升高,试验组较对照组更高,差异有统计学意义(t=10.657、4.413、3.655、6.451、25.120、11.356,P<0.05)。治疗期间,试验组不良反应发生率为5.00%,低于对照组的26.00%(χ^(2)=4.336,P<0.05)。结论相比利培酮,齐拉西酮可明显升高精神分裂症患者血清GABA水平,降低其血清INH、Ach水平,改善神经功能,同时可改善患者精神症状及认知功能,提高疗效,但二者安全性相当。
Objective To analyze the changes in cognitive function,γ-aminobutyric acid(GABA),inhibin(INH),and acetylcholine(Ach)in patients with schizophrenia after applying ziprasidone and risperidone treatment.Methods A randomized numerical table method was used to divide 100 patients with schizophrenia selected from the psychiatric department of the Fifth Hospital of Tangshan City,Hebei Province,from June 2020 to June 2023 into a test and a control group of 50 cases each.The test and control groups were orally administered ziprasidone hydrochloride tablets and risperidone tablets,respectively,for a period of 2 months.Compare the efficacy(2 months after treatment),psychiatric symptom scores,cognitive function,neurotransmitter levels(before treatment and 2 months after treatment),and safety(during treat-ment)between two groups.Results After 2 months of treatment,the total effective rate of the experimental group was 92.00%,which was higher than 76.00%of the control group,and the difference was statistically significant(χ^(2)=4.762,P<0.05).Comparison between the two groups after 2 months of treatment and before treatment,the positive,negative,psychopathological symptom scores,total scores,and serum INH and Ach levels were lower,and were lower in the experimental group compared to the control group,and the difference was statistically significant(t=9.449,5.243,20.206,17.310,15.229,7.345,P<0.05).Comparison between the two groups after 2 months of treatment and before treatment,the immediate,delayed,visual,delayed vi-sual memory scores,total scores,and serum GABA levels were higher,and were higer in the experimental group compared to the control group,with statistically significant differences(t=10.657,4.413,3.655,6.451,25.120,11.356,P<0.05).During the treatment period,the incidence of adverse reactions in the experi-mental group was 5.00%,lower than the control groups 26.00%(χ^(2)=4.336,P<0.05).Conclusion Com-pared with risperidone,ziprasidone could significantly increase the serum GABA level in patients with schizo-phrenia
作者
王凤杰
李涛
孟凡娇
WANG Fengjie;LI Tao;MENG Fanjiao(Department of Psychiatry,Fifth Hospital of Tangshan City,Tangshan,Hebei,China,063000)
出处
《分子诊断与治疗杂志》
2024年第7期1332-1336,共5页
Journal of Molecular Diagnostics and Therapy
基金
河北省省级科技计划自筹经费项目(182777154)。
