摘要
目的 探讨血清肌红蛋白(Mb)、生长分化因子-15(GDF-15)、去整合素-金属蛋白酶9(ADAM9)与35岁以下急性心肌梗死(AMI)发生及心源性死亡的关系。方法 选取2016年1月至2023年1月内蒙古自治区人民医院收治的115例AMI患者作为AMI组,并根据观察期内(随访6个月)心源性死亡情况分为死亡组与存活组,另选同期60名健康体检者作为对照组。记录死亡组与存活组临床资料及入院时血清Mb、GDF-15、ADAM9水平并进行比较,采用Logistic回归方程分析35岁以下AMI患者心源性死亡发生的影响因子,采用受试者工作特征(ROC)曲线评价血清Mb、GDF-15、ADAM9单独或联合对35岁以下AMI患者6个月内心源性死亡发生的预测价值。结果 AMI组患者的血清Mb、GDF-15、ADAM9水平均显著高于对照组,差异有统计学意义(P<0.05);AMI组患者观察期内共发生心源性死亡30例,发生率26.07%;死亡组患者高血压占比及血清Mb、GDF-15、ADAM9水平明显高于存活组,差异有统计学意义(P<0.05);Logistic回归分析显示,血清Mb、GDF-15、ADAM9水平升高是35岁以下AMI患者心源性死亡发生的危险因子(P<0.05);35岁以下AMI患者血清Mb、GDF-15、ADAM9两两正相关(P<0.05);血清Mb、GDF-15、ADAM9联合预测35岁以下AMI患者发生心源性死亡的AUC为0.877,高于三者单独预测的0.752、0.762、0.720(P<0.05)。结论 35岁以下AMI患者血清Mb、GDF-15、ADAM9明显升高,联合检测此三项指标对35岁以下AMI患者6个月内心源性死亡发生有较好的预测价值。
Objective To investigate the relationship between serum myoglobin(Mb),growth differentiation factor-15(GDF-15),a distegrinin and a metalloprotease 9(ADAM9)and acute myocardial in-farction(AMI),cardiogenic death in patients under 35 years old.Methods A total of 115 patients with AMI admitted to Inner Mongolia People’s Hospital from January 2016 to January 2023 were selected.According to the presence or absence of cardiogenic death during observation period(6 months of follow-up),they were di-vided into a death group and a survival group.Meanwhile,60 healthy individuals were chosen as the control group.Clinical data and serum Mb,GDF-15 and ADAM9 levels at admission were compared between the death group and the survival group.Logistic regression equation was used to screen the influencing factors for cardiogenic death in patients with AMI under 35 years old.The predictive value of serum Mb,GDF-15,ADAM9,and their combination for cardiogenic death in patients with AMI under 35 years old was evaluated using receiver operating characteristic(ROC)curves.Results Serum Mb,GDF-15 and ADAM9 levels in the AMI group were significantly higher than those in the control group,and the differences were statistically sig-nificant(P<0.05).In the AMI group,cardiogenic death occurred in 30 cases during the observation period,with an incidence rate of 26.07%.The proportion of patients with hypertension and serum Mb,GDF-15 and ADAM9 levels in the death group were significantly higher than those in the survival group,and the differ-ences were statistically significant(P<0.05).Logistic regression analysis showed that elevated serum Mb,GDF-15 and ADAM9 levels were risk factors for cardiogenic death in patients with AMI under 35 years old(P<0.05).Serum Mb,GDF-15 and ADAM9 were positively correlated in patients with AMI under 35 years old(P<0.05).The AUC of serum Mb combined with GDF-15 and ADAM9 for predicting cardiogenic death in patients with AMI under 35 years old was 0.877,which was greater than that of prediction using a single indi-c
作者
祁亚楠
赵平
田志强
张宇
高文慧
QI Yanan;ZHAO Ping;TIAN Zhiqiang;ZHANG Yu;GAO Wenhui(Department of Cardiovascular Medicine,Inner Mongolia People’s Hospital,Inner Mongolia Autonomous Region,China,010017;Department of Clinical Laboratory,the Affiliated Hospital of Inner Mongolia Medical University,Inner Mongolia Autonomous Region,China,010017)
出处
《分子诊断与治疗杂志》
2024年第7期1315-1319,共5页
Journal of Molecular Diagnostics and Therapy
基金
内蒙古自治区卫生健康科技计划项目(202301039)。
