摘要
Intestinal metaplasia(IM)is a key stage in the tumorigenic Correa cascade from gastritis to final intestinal-type gastric cancer(GC).1 Helicobacter pylori(H.pylori)infection is the most common trigger of IM,and it promotes GC progression through induction of gastric epithelial transition.2 Currently,the mechanism by which H.pylori infection promotes tumorigenesis in IM patients is poorly understood.Zhang et al.established a single-cell transcriptomic atlas on premalignant lesions and identified biomarkers of gastric early-malignant cells,providing an opportunity to explore the molecular mechanism of GC progression at the molecular level.
基金
the National Natural Science Foundation of China(NSFC)(32070792 to J.Z.)
the Startup Foundation of Dermatology Hospital,Southern Medical University(2019RC06 to J.Z.).
