摘要
目的:探讨雌二醇片/雌二醇地屈孕酮片(芬吗通)周期治疗和连续治疗对卵巢早衰患者临床效果与安全性的影响。方法:选取2022年4月—2023年4月庆阳市人民医院收治的60例卵巢早衰患者。根据随机数表法将其分为对照组和观察组,各30例。对照组给予芬吗通周期治疗,观察组给予芬吗通连续治疗。比较两组临床疗效,治疗前、治疗6个周期后子宫内膜厚度、性激素指标,不良反应。结果:两组总有效率比较,差异无统计学意义(P>0.05)。治疗6个周期后,两组子宫内膜厚度明显增加,观察组子宫内膜厚度高于对照组,差异有统计学意义(P<0.05)。治疗前及治疗6个周期后,两组促黄体生成激素(luteinizing hormone,LH)、卵泡刺激素(follicle stimulating hormone,FSH)、雌二醇(estradiol,E_(2))水平比较,差异无统计学意义(P>0.05),治疗6个周期后,两组FSH、LH水平降低,E_(2)水平升高,差异有统计学意义(P<0.05)。观察组不良反应发生率高于对照组,差异有统计学意义(P<0.05)。结论:采用芬吗通进行周期治疗或连续治疗,均有各自优势,周期性用药的安全性相对较高,而连续性用药对子宫内膜的改善效果更好,临床需结合实际情况选择合适的治疗方案。
Objective:To investigate the effect of periodic therapy and continuous therapy of Estradiol Tablets/Estradiol and Dydrogesterone Tablets(Femostone)on the clinical efficacy and safety of patients with premature ovarian failure.Method:A total of 60 patients with premature ovarian failure treated in Qingyang People's Hospital from April 2022 to April 2023 were selected.They were divided into control group and observation group according to random number table method,with 30 cases in each group.The control group was given periodic treatment of Femostone,and the observation group was given continuous treatment of Femostone.The clinical efficacy,endometrial thickness,sex hormone indexes before and after 6 cycles of treatment and adverse reactions were compared between the two groups.Result:There was no significant difference in total effective rate between the two groups(P>0.05).After 6 cycles of treatment,endometrial thickness increased significantly in the two groups,and the endometrial thickness in the observation group was higher than that in the control group,the differences were statistically significant(P<0.05).Before and after 6 cycles of treatment,the levels of luteinizing hormone(LH),follicle stimulating hormone(FSH)and estradiol(E_(2))in the two groups were compared,and there were no statistical significance between the two groups(P>0.05).After 6 cycles of treatment,FSH and LH levels decreased and E_(2) levels increased,and the differences were statistically significant(P<0.05).The incidence of adverse reactions in observation group was higher than that in control group,and the difference was statistically significant(P<0.05).Conclusion:Periodic treatment or continuous treatment with Femostone has its own advantages.The safety of periodic treatment is relatively high,while continuous treatment has better improvement effect on endometrial.Therefore,it is necessary to select the appropriate treatment plan according to the actual situation in clinic.
作者
王志萍
王彦花
WANG Zhiping;WANG Yanhua(Qingyang People's Hospital,Qingyang 745000,China;不详)
出处
《中外医学研究》
2024年第19期119-123,共5页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
芬吗通
周期治疗
连续治疗
卵巢早衰
效果
安全性
Femostone
Periodic treatment
Continuous treatment
Premature ovarian failure
Effect
Security
