摘要
人体内部分细胞的种类变化和生理状态是人体健康的重要指标,对细胞进行生化分析是医学诊断的重要手段。基于成像和质谱的流式细胞术,在细胞分析上具有高通量、特异性强的优点,能够表征人体血液或组织样本中特定的细胞类型和形态特征,从而实现疾病的诊断。本文综述了成像流式细胞术(IFC)、质谱流式细胞术(CyTOF)和成像质谱细胞术(IMC)在肿瘤学、免疫学、血液学等医学领域中最新的应用进展。
The variety and physiological state of some cells in human body are important indicators of human health.Hence,biochemical analysis of cells is an important means of medical diagnosis.Imaging and mass spectrometry based flow cytometry has the advantages of high throughput and specificity in cellular assays,which can characterize the types and morphological of specific cells in human blood or tissue samples to realize the disease diagnostic.Thus,this review summarizes the latest advances of imaging flow cytometry(IFC),cytometry by time-of-flight(CyTOF)and imaging mass cytometry(IMC)in oncology,immunology,and hematology.
作者
杨瑞
张纪媛
于玉洁
张顺心
王合宇
刘大喜
田亮
崔建升
YANG Rui;ZHANG Jiyuan;YU Yujie;ZHANG Shunxin;WANG Heyu;LIU Daxi;TIAN Liang;CUI Jiansheng(College of Environmental Science and Engineering,Hebei University of Science and Technology,Shijiazhuang 050018,China;Hebei Key Laboratory of Pollution Prevention Biotechnology,Shijiazhuang 050018,China)
出处
《分析试验室》
EI
CAS
CSCD
北大核心
2024年第6期914-924,共11页
Chinese Journal of Analysis Laboratory
基金
河北省自然科学基金(B2021208029)
河北省高等学校科学技术研究项目(QN2023111)
河北省科技厅京津冀协同创新共同体建设专项(20543901D)资助。
