摘要
目的观察四逆散合金铃子散加减联合推拿治疗小儿肠系膜淋巴结炎的疗效。方法将2022年1月~2023年2月收治的符合要求的80例肠系膜淋巴结炎气滞血瘀证患儿随机分为对照组和观察组(每组40例)。对照组采用常规治疗,观察组在常规组基础上予四逆散合金铃子散加减联合推拿治疗。比较两组临床总有效率,治疗前、治疗后3、5、7和10 d腹痛程度评分,腹痛缓解、消失时间;根据超声检查结果比较两组治疗前后肠系膜淋巴结纵径、横径;比较两组治疗前后的中医证候评分,降钙素原(PCT)、降钙素基因相关肽(CGRP)和内皮素-1(ET-1)水平。结果治疗后,观察组临床疗效总有效率为90.00%,较对照组的72.50%高(P<0.05);治疗后3、5、7和10 d,观察组腹痛程度评分均低于对照组(P<0.05);治疗后,观察组腹痛缓解和消失时间均短于对照组(P<0.05);治疗后,两组肠系膜淋巴结的纵径、横径均较治疗前缩小(P<0.05),且观察组小于对照组(P<0.05);治疗后,两组中医证候评分均明显降低(P<0.05),且观察组低于对照组(P<0.05);治疗后两组PCT和ET-1水平明显降低(P<0.05),且观察组低于对照组(P<0.05),治疗后两组CGRP水平明显升高(P<0.05),且观察组高于对照组(P<0.05)。结论四逆散合金铃子散加减联合推拿治疗小儿肠系膜淋巴结炎气滞血瘀证患者,可显著减轻腹痛,缩小肠系膜淋巴结,减轻中医证候,并可改善生化指标水平,临床疗效优于单纯西医治疗。
Objective To observe the clinical efficacy of Sini San and modified Jinlingzi San combined with massage in the treatment of children with mesenteric lymphadenitis.Methods 80 eligible children with mesenteric lymphadenitis of Qi stagnation and blood stasis syndrome admitted from January 2022 to February 2023 were randomly divided into a control group and an observation group(each group had 40 cases).The control group was received routine treatment,while the observation group was received Sini San and modified Jinlingzi San combined with massage for treatment on the basis of the routine group.The total effective rate of clinical efficacy,the abdominal pain severity scores before treatment and at 3,5,7,10 days after treatment,the time of relief and disappearance of abdominal pain of the two groups were compared;the longitudinal and transverse diameters of mesentery lymph nodes before and after treatment of the two groups were compared according to the results of ultrasound examination;The TCM syndrome scores,the levels of PCT,CGRP,and ET-1 before and after treatment between the two groups were compared.Results After treatment,the total effective rate of clinical efficacy in the observation group was 90.00%,which was higher than 72.50%in the control group(P<0.05);On the 3,5,7 and 10 days after treatment,the abdominal pain severity score of the observation group was lower than that of the control group(P<0.05);after treatment,the relief and disappearance time of abdominal pain in the observation group was shorter than that in the control group(P<0.05);after treatment,the longitudinal and transverse diameters of mesentery lymph nodes in both groups were smaller than those before treatment,and the observation group was lower than the control group(P<0.05);after treatment,the TCM syndrome scores of both groups significantly decreased(P<0.05),and the observation group was lower than the control group(P<0.05);after treatment,the levels of PCT and ET-1 in both groups were significantly reduced(P<0.05),and the observation gr
作者
吕化伟
LV Hua-wei(Qingdao Jimo District Traditional Chinese Medicine Hospital Affiliated to Shandong University of Traditional Chinese Medicine,Qingdao 266200,China)
出处
《中国处方药》
2024年第7期140-143,共4页
Journal of China Prescription Drug
