摘要
During cell differentiation,growth,and development,cells can respond to extracellular stimuli through communication channels.Pannexin(Panx)family and connexin(Cx)family are two important types of channel-forming proteins.Panx family contains three members(Panx1-3)and is expressed widely in bone,cartilage and muscle.Although there is no sequence homology between Panx family and Cx family,they exhibit similar configurations and functions.Similar to Cxs,the key roles of Panxs in the maintenance of physiological functions of the musculoskeletal system and disease progression were gradually revealed later.Here,we seek to elucidate the structure of Panxs and their roles in regulating processes such as osteogenesis,chondrogenesis,and muscle growth.We also focus on the comparison between Cx and Panx.As a new key target,Panxs expression imbalance and dysfunction in muscle and the therapeutic potentials of Panxs in joint diseases are also discussed.
基金
supported by National Key R&D Program of China(2019YFA0111900,2023YFB4606705)
National Natural Science Foundation of China(No.82072506,82272611,92268115,82302764)
Hunan Provincial Science Fund for Distinguished Young Scholars(No.2024JJ2089)
Science and Technology Innovation Program of Hunan Province(No.2021RC3025,2023SK2024)
Provincial Natural Science Foundation of Hunan(No.2022JJ70162,2023JJ30949)
National Clinical Research Center for Geriatric Disorders(Xiangya Hospital,Grant No.2021KFJJ02 and 2021LNJJ05)
National Clinical Research Center for Orthopedics,Sports Medicine and Rehabilitation(2021-NCRC-CXJJ-PY-40).
