摘要
结肠癌是消化道最常见的肿瘤之一,肿瘤发病率居世界第三,癌症相关死亡人数居世界第二。结肠癌的治疗通常包括手术切除后化疗、放疗、免疫治疗,有时也包括靶向治疗。然而,许多患者因复发或药物治疗失败而死亡。因此,确定新的治疗策略将有助于结肠癌的治疗。近年来,中医对铁死亡的研究越来越多,铁死亡是一种新的程序性细胞死亡形式,具有明显不同的遗传、生化和形态学特征。中药具有多靶点、副作用小的特点,在抗肿瘤研究方面取得了长足的进展。铁死亡在肿瘤的发生发展中发挥重要作用,尤其对消化系统肿瘤存在较大的潜在临床转化研究意义。现对中药调控铁死亡的机制及其在结肠癌中的相关进展进行综述,以期发现更多与铁死亡相关的因素,为中药治疗结肠癌提供理论支持。
Colon cancer is one of the most common tumors of the digestive tract,ranking the third in tumor incidence worldwide,and the number of cancer-related deaths ranks the second in the world.The treatment of colon cancer usually includes chemotherapy after surgical removal,radiotherapy,immunotherapy,and sometimes targeted therapy.However,many patients die from recurrence or failure of medication.Therefore,the determination of new therapeutic strategies may contribute to the treatment of colon cancer.In recent years,there has been an increasing number of studies on ferroptosis in Traditional Chinese Medicine.Ferroptosis is a new form of programmed cell death with markedly different genetic,biochemical and morphological characteristics.Traditional Chinese Medicine has the characteristics of multi-target and small side effects,and has made great progress in anti-tumor research.Ferroptosis plays an important role in the occurrence and development of tumors,especially for digestive system tumors,which has great potential clinical translational research significance.This article reviews the mechanism of Traditional Chinese Medicine in regulating ferroptosis and its related progress in colon cancer,in order to find more factors related to ferroptosis and provide theoretical support for TCM treatment of colon cancer.
作者
代雪莉
万朝星
叶菁
DAI Xueli;WAN Chaoxing;YE Jing(Jiangxi University of Traditional Chinese Medicine,Master Class of 2022;School of Clinical Medicine,Jiangxi University of Traditional Chinese Medicine,Nanchang 330006,Jiangxi,China)
出处
《现代诊断与治疗》
CAS
2024年第5期673-677,共5页
Modern Diagnosis and Treatment
基金
江西中医药大学中医学人才临床实践技能培养模式改革虚拟教研室建设项目(项目编号6002/2252300115)。
关键词
铁死亡
中医药
结肠癌
Ferroptosis
Traditional Chinese Medicine
Colon cancer
