摘要
目的:观察竭七胶囊联合低剂量低分子肝素的中西医结合疗法对断指再植术后患者的抗凝效果。方法:将2022年1月至2023年1月我院收治的76例断指再植病例作为研究对象,随机分为试验组和对照组,每组各38例。在保留断指再植术后常规治疗的基础上,对照组给予低分子肝素4000或5000 AXaIU(按体重)腹壁皮下注射,qd,连续治疗7 d;试验组在联合使用竭七胶囊(餐后口服,0.9 g,tid),连续使用7 d的同时,给予低分子肝素2000 AXaIU腹壁皮下注射,qd。比较两组患者治疗前及治疗1、3、7 d时的凝血功能指标[活化部分凝血活酶时间(APTT)、国际标准化比值(INR)、凝血酶原时间(PT)、血小板计数(PLT)]。结果:治疗前两组患者凝血功能指标APTT、INR、PT、PLT比较,差异均无统计学意义(P>0.05)。术后抗凝治疗1、3 d时,对比治疗前,两组患者INR、PT及APTT均增高,PLT均下降(P<0.05);术后7 d,两组患者APTT、INR、PT、PLT水平与治疗前比较,差异均无统计学意义(P>0.05)。组间比较,术后抗凝治疗1、3、7 d,两组患者APTT、INR、PT、PLT水平差异均无统计学意义(P>0.05)。结论:竭七胶囊联合低剂量低分子肝素的中西医结合疗法在断指再植术后的抗凝效果与高剂量低分子肝素效果相当;竭七胶囊的应用可减少临床低分子肝素的使用剂量,从而提高用药安全性。
Objective:To observe the anticoagulation effect of Jieqi capsules combined with low dose of low molecular weight heparin(LMWH)in patients after replantation of severed fingers.Methods:A total of 76 cases of severed finger replantation treated in our hospi-tal from January 2022 to January 2023 were randomly divided into the test group and the control group,with 38 cases in each group.On the basis of conventional treatment after replantation of severed fingers,the control group received LMWH 4000 or 5000 AXaIU(accord-ing to body weight)abdominal subcutaneous injection,qd,continuous treatment for 7 d,and the test group received Jieqi capsules orally taken after meal(0.9 g,tid)for 7 d combined with LMWH 2000 AXaIU abdominal subcutaneous injection,qd.The coagulation func-tion indexes[activated partial thromboplastin time(APTT),international normalized ratio(INR),prothrombin time(PT),and platelet count(PLT)]of the two groups of patients were compared before treatment and at the 1 d,3 d and 7 d of the treatment.Results:Before treatment,the APTT,INR,PT and PLT levels of the two groups of patients had no statistical difference(P>0.05).At the 1 d and 3 d of postoperative anticoagulant treatment,the INR,PT and APTT levels increased and PLT level decreased in both groups compared with before treatment(P<0.05).On the 7 d of postoperative anticoagulant treatment,the APTT,INR,PT and PLT levels of the two groups of patients had no statistical difference compared with those before treatment(P>0.05).There was no statistical difference in APTT,INR,PT and PLT levels between the two groups of patients on the 1 d,3 d and 7 d of postoperative anticoagulation treatment(P>0.05).Conclusion:The anticoagulant effect of Jieqi capsules combined with low dose LMWH after severed finger replantation is similar to that of high dose LMWH.The application of Jiaqi capsules can reduce the use dose of LMWH,and improve the safety of medication.
作者
王道明
张沈屹婷
WANG Daoming;ZHANG Shenyiting(Department of Hand Surgery,Quanzhou Orthopedic-Traumatological Hospital,Fujian Quanzhou 362200,China)
出处
《中国医药导刊》
2024年第6期576-579,共4页
Chinese Journal of Medicinal Guide
基金
泉州市科技计划项目(2022NS013)。
关键词
竭七胶囊
低分子肝素
断指再植
抗凝效果
Jieqi capsules
Low molecular weight heparin
Replantation of severed finger
Anticoagulation effect
