摘要
发展了一种Cu(OAc)_(2)介导吲哚衍生物的C(2)选择性甲硫基化与三氘甲硫基化反应.该转化以二甲基亚砜(DMSO)作为甲硫基来源与溶剂,以中等至良好收率得到C(2)-甲硫基取代吲哚,当选用DMSO-d_(6)作为反应试剂时,也可合成得到C(2)-三氘甲硫基取代吲哚.同时,该反应不依赖于高温条件,转化可能涉及自由基途径.
Cu(OAc)_(2)mediated C(2)-selective d_(3)-methylthiolation and methylthiolation of indoles were developed.With the choice of dimethyl sulfoxide(DMSO)as sulfur source and solvent,methylthiolation reaction could be achieved in moderate to good yields,and d_(3)-methylthiolated products could also be obtained with DMSO-d_(6)as reagent just by prolong the reaction time.Moreover,this methylthiolation didn't depend on high temperature,and radical pathway might be involved in this transformation.
作者
张娟
王奕森
田钰
徐晶
高文超
常宏宏
孟凡会
杨朋
Zhang Juan;Wang Yisen;Tian Yu;Xu Jing;Gao Wenchao;Chang Honghong;Meng Fanhui;Yang Peng(College of Biomedical Engineering,Taiyuan University of Technology,Taiyuan 030024;Shanxi Tihondan Pharmaceutical Technology Co.Ltd.,Jinzhong,Shanxi 030600;State Key Laboratory of Clean and Efficient Coal Utilization,Taiyuan University of Technology,Taiyuan 030024;College of Chemistry,Chemical Engineering and Materials Science,Shandong Normal University,Jinan 250014)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2024年第5期1576-1583,共8页
Chinese Journal of Organic Chemistry
基金
太原理工大学省部共建煤基能源清洁高效利用国家重点实验室开放基金(No.SKL202102)
山西省自然科学基金(Nos.20210302124123,202303021211033)资助项目。
