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痔瘘洗剂联合肛泰软膏对肛周脓肿术后创面愈合及疼痛的影响

Effect of Hemorrhoid Fistula Lotion Combined with Gangtai Ointment on Wound Healing and Pain After Surgery for Perianal Abscess
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摘要 目的:观察痔瘘洗剂联合肛泰软膏治疗对肛周脓肿术后创面愈合及疼痛的影响。方法:将110例肛周脓肿患者随机分为对照组和联合组各55例,2组均给予肛周脓肿一次性根治手术治疗,对照组术后采取抗生素及肛泰软膏治疗,联合组在对照组基础上给予痔瘘洗剂治疗。比较2组临床疗效、创面愈合情况、疼痛视觉模拟评分法(VAS)评分、创面渗液、肉芽组织生长情况以及血清炎症因子[肿瘤坏死因子-α(TNF-α)、血管内皮生长因子(VEGF)]水平。结果:联合组总有效率为94.55%,对照组为80.00%,2组比较,差异有统计学意义(P<0.05)。术后,联合组上皮新生时间、腐肉脱落时间、创面愈合时间均短于对照组,差异有统计学意义(P<0.05)。术后7、14 d,2组VAS、创面渗液、肉芽组织生长评分较术后当天降低(P<0.05),并呈下降趋势(P<0.05);且联合组在相同时间点VAS、创面渗液、肉芽组织生长评分均低于对照组(P<0.05)。术后7、14 d,2组血清TNF-α水平较术后当天降低(P<0.05),并呈下降趋势(P<0.05),且联合组在相同时间点TNF-α水平均低于对照组(P<0.05);2组VEGF水平较术后当天升高(P<0.05),并呈升高趋势(P<0.05),且联合组在相同时间点VEGF水平均高于对照组(P<0.05)。结论:痔瘘洗剂联合肛泰软膏能够缓解肛周脓肿患者术后疼痛,加快创面愈合,降低炎症水平,疗效显著。 Objective:To observe the effect of the therapy of Hemorrhoid Fistula Lotion combined with Gangtai Ointment on wound healing and pain after surgery for perianal abscess.Methods:A total of 110 patients with perianal abscess were randomly divided into the control group and the combination group,with 55 cases in each group.Both groups were treated with one-time radical surgery for perianal abscess;the control group was treated with antibiotics and Gangtai Ointment after surgery;the combination group was treated with Hemorrhoid Fistula Lotion on the basis of the control group.The clinical effects,wound healing,scores of Visual Analogue Scale(VAS),wound effusion,granulation tissue growth and levels of serum inflammatory factors[tumor necrosis factor-α(TNF-α)and vascular endothelial growth factor(VEGF)]were compared between the two groups.Results:The total effective rate was 94.55%in the combination group and 80.00%in the control group,the difference being significant(P<0.05).After surgery,the epithelial regeneration time,rotting meat shedding time and wound healing time in the combination group were shorter than those in the control group,differences being significant(P<0.05).After 7 and 14 days after surgery,scores of VAS,wound effusion and granulation tissue growth in the two groups were decreased when compared with those on the day after surgery(P<0.05),and showed a decreasing trend(P<0.05);the scores of VAS,wound effusion and granulation tissue growth in the combination group were lower than those in the control group at the same time point(P<0.05).After 7 and 14 days after surgery,the serum TNF-αlevels in the two groups were decreased when compared with those on the day after surgery(P<0.05),and showed a decreasing trend(P<0.05),and the level of TNF-αin the combination group was lower than that in the control group at the same time point(P<0.05);the VEGF levels in both groups were increased when compared with those on the day after surgery(P<0.05),and showed an increasing trend(P<0.05),and the VEGF level in th
作者 刘慧泽 孙曦 LIU Huize;SUN Xi(Department of Proctology,Hangzhou Hospital of Traditional Chinese Medicine,Hangzhou Zhejiang 310000,China)
出处 《新中医》 CAS 2024年第12期71-75,共5页 New Chinese Medicine
关键词 肛周脓肿 围手术期 痔瘘洗剂 肛泰软膏 创面愈合 疼痛 Perianal abscess Perioperative period Hemorrhoid Fistula Lotion Gangtai Ointment Wound healing Pain
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