摘要
目的:探讨早卵泡期长效长方案联合重组黄体生成素(r-LH)对卵巢高反应人群排卵和妊娠结局的影响。方法:选入2019年1月~2023年3月在我院行早卵泡期长效长方案促排卵的卵巢高反应患者150例,根据是否添加r-LH分为对照组(未添加r-LH,n=75)和观察组(添加r-LH,n=75)。比较两组的促排卵相关指标和妊娠结局。结果:观察组Gn天数、Gn总量、HCG日血清LH水平、优质胚胎率均显著高于对照组,获卵数显著少于对照组(P<0.05)。两组降调天数、Gn启动量以及HCG日E2、P水平和子宫内膜厚度、临床妊娠率、活产率、流产率比较无差异(P>0.05)。结论:卵巢高反应患者行早卵泡期长效长方案促排卵时,添加r-LH可显著增加体内LH水平,提高优质卵泡率,对妊娠结局具有一定改善作用。
Objective:To explore the effect of early follicular phase long-acting protocol combined with whole process recombinant luteinizing hormone(r-LH)on ovulation and pregnancy outcomes of high ovarian response.Methods:A total of 150 cases high ovarian response patients who underwent long-term ovulation induction in our hospital from January 2021 to March 2023 were divided into Matched group(r-LH was added,n=75)and observation group(r-LH was added,n=75 according to r-LH).Oovulation-related indicators and pregnancy outcomes were compared between the two groups.Results:Gn days,total Gn days,HCG daily serum LH level,and high-quality embryo rate were higher than that of the observation group,and the number of eggs obtained was less than that of the Matched group(P<0.05).There was no difference between the days of reduction,Gn initiation,E2,P level,and endometrial thickness,clinical pregnancy rate,live birth rate,and abortion rate between the two groups(P>0.05).Conclusion:The addition of r-LH significantly increased LH levels in vivo and improved the rate of high-quality follicles when ovulation was promoted in patients with ovarian hyperresponsiveness undergoing the early follicular phase of the long-acting,long-lasting regimen,which had an improved effect on pregnancy outcome.
作者
余晓燕
杨惠林
李燕子
马英兰
王春梅
李琴
YU Xiao-yan;YANG Hui-lin;LI Yan-zi;MA Ying-lan;WANG Chun-mei;LI Qin(Reproductive Center,Qinghai Red Cross Hospital,Xining,Qinghai,810000,China;Gynecology Department,Qinghai Red Cross Hospital,Xining,Qinghai,810000,China;Department of Obstetrics and Gynecology,Qinghai University Affiliated Hospital,Xining,Qinghai,810000,China)
出处
《现代生物医学进展》
CAS
2024年第12期2341-2345,共5页
Progress in Modern Biomedicine
基金
青海省卫生健康委员会指导性计划项目(2020-wjzdx-62)。
关键词
卵巢高反应
长效长方案
早卵泡期
重组黄体生成素
排卵
妊娠结局
High ovarian response
Long term rectangular plan
Early follicular phase
Recombinant luteinizing hormone
Ovulation
Pregnancy outcome
