摘要
目的:分析干扰素γ(Interferon-γ,IFN-γ)、纤维蛋白单体(Fibrin monomer,FM)及肺炎支原体抗体(Mycoplasma pneumoniae antibody,MP-Ab)检测在小儿支原体肺炎感染中的临床意义。方法:选取2020年11月至2023年11月本院收治的103例支原体肺炎患儿作为研究对象,设定为观察组,另选取同期在本院行体检各项正常者60例健康体检儿童作为对照组,对比两组血清IFN-γ、FM水平以及MP-Ab含量;对比观察组不同病情程度患儿血清IFN-γ、FM水平以及MP-Ab含量;以病原学检查为金标准,分析血清IFN-γ、FM及MP-Ab检测对支原体肺炎病情的评估价值。结果:103例支原体肺炎患儿中,其中72例属于急性期,31例属于恢复期;72例急性期患儿中18例为重症支原体肺炎,54例为轻症支原体肺炎。观察组中急性期、恢复期患儿血清IFN-γ、FM水平与MP-Ab含量及各指标阳性检出率均显著高于对照组,而急性期显著高于恢复期(P<0.05)。观察组急性期中重症患儿血清IFN-γ、FM水平与MP-Ab含量及各指标阳性检出率均显著高于轻症患儿,比较差异具有统计学意义(P<0.05)。结论:干扰素γ、FM水平及MP-Ab含量在支原体肺炎患儿中呈现高表达,且随着病情的加重而呈逐渐升高趋势,对患儿疾病的早期诊断及病情评估有潜在的应用价值。
Objective:To investigate the clinical significance of interferon-γ(IFN-γ),fibrin monomer(FM),and Mycoplasma pneumoniae antibody(MP-Ab)detection in children with Mycoplasma pneumoniae infection.Methods:A total of 103 children with Mycoplasma pneumoniae pneumonia admitted to our hospital from November 2020 to November 2023 were enrolled as the study group.Sixty healthy children who underwent physical examination and showed normal results during the same period were selected as the control group.The serum levels of IFN-γand FM and the contents of MP-Ab in the two groups were compared.The serum levels of IFN-γ,FM and the contents of MP-Ab in children with different disease severity in the observation group were compared.With pathological examination as the gold standard,the evaluation value of serum IFN-γ,FM and MP-Ab detection for Mycoplasma pneumoniae pneumonia was analyzed.Results:Among the 103 children with Mycoplasma pneumoniae pneumonia,72 were in the acute stage and 31 were in the recovery stage.Among the 72 children in the acute stage,18 had severe Mycoplasma pneumoniae pneumonia and 54 had mild Mycoplasma pneumoniae pneumonia.The serum levels of IFN-γand FM and the contents of MP-Ab in the acute and recovery stages of the observation group were significantly higher than those in the control group,and the acute stage was significantly higher than the recovery stage(P<0.05).The serum levels of IFN-γand FM and the contents of MP-Ab in children with severe Mycoplasma pneumoniae pneumonia in the acute stage were significantly higher than those in children with mild Mycoplasma pneumoniae pneumonia,and the differences were statistically significant(P<0.05).Conclusion:The levels of IFN-γ,FM and MP-Ab are highly expressed in children with Mycoplasma pneumoniae pneumonia and increase gradually with the aggravation of the disease.They have the potential to be applied to the early diagnosis and evaluation of the disease in children.
作者
高利华
朱丽
满海侠
GAO Lihua;ZHU Li;MAN Haixia(Anhui Provincial General Hospital of Armed Police,Anhui Hefei 230041,China)
出处
《河北医学》
CAS
2024年第7期1206-1210,共5页
Hebei Medicine
基金
2022年安徽省重点研究与开发计划项目,(编号:2022e07020002)。
