摘要
目的探析血府逐瘀汤对高血压患者血压水平及血管内皮功能的影响。方法采用前瞻性研究,选取医院2022年1月—2023年6月收治的高血压患者90例作为研究对象,以随机数字法分为对照组和观察组,各45例,对照组给予常规治疗,观察组加用血府逐瘀汤治疗,持续治疗3个月,比较两组临床疗效、血压(舒张压、收缩压)以及血管内皮功能[一氧化氮(NO)、内皮素-1(ET-1)]。结果观察组总有效率较对照组高,差异有统计学意义(P<0.05)。两组治疗3个月后,收缩压、舒张压均下降,且相较于对照组,观察组下降更显著(P<0.05);NO上升、ET-1下降,相较于对照组,观察组变化更显著(P<0.05)。结论血府逐瘀汤治疗高血压患者效果显著,可有效调节血压水平,改善血管内皮功能。
Objective To explore the effects of Xuefu Zhuyu Decoction on blood pressure levels and vascular endothelial functions in hypertensive patients.Methods A prospective study was conducted,90 hypertensive patients admitted to hospital from January 2022 to June 2023 were selected as study subjects,and they were divided into control group and observation group by randomized numerical method,with 45 cases in each group.The control group were given conventional treatment,and based on which the observation group were treated with Xuefu Zhuyu Decoction.Both groups were continuously treated for 3 months.And then,clinical efficacy,blood pressure(diastolic blood pressure and systolic blood pressure),and vascular endothelial functions(nitric oxide[NO]and endothelin-1[ET-1])of the two groups were compared.Results The total effective rate of the observation group was higher than that of the control group,and difference was statistically significant(P<0.05).After 3 months of treatment,systolic blood pressure and diastolic blood pressure decreased,and compared with the control group,decrease in the observation group was more significant(P<0.05);NO increased and ET-1 decreased,and compared to the control group,the changes in the observation group were more significant(P<0.05).Conclusion The effect of Xuefu Zhuyu Decoction in treating hypertensive patients is remarkable,which can effectively regulate the blood pressure levels and improve the endothelial functions.
作者
林慧慧
罗忠金
LIN Huihui;LUO Zhongjin(Department of Acupuncture and Massage,Traditional Chinese Medicine Hospital of Zherong County,Zherong 355300,Fujian,China;Department of Chinese Traditional Medicine,Traditional Chinese Medicine Hospital of Zherong County,Zherong 355300,Fujian,China)
出处
《右江医学》
2024年第6期544-547,共4页
Chinese Youjiang Medical Journal
关键词
血府逐瘀汤
高血压
血管内皮功能
一氧化氮
内皮素-1
Xuefu Zhuyu Decoction
hypertension
vascular endothelial function
nitric oxide(NO)
endothelin-1(ET-1)
