摘要
目的:基于数据挖掘的方法研究中医药治疗胆囊切除术后综合征的用药规律。方法:检索中文科技期刊数据库(维普)、中国学术期刊数据库(万方)、国家知识基础设施数据库(知网)中中医药治疗胆囊切除后不良反应的相关文献,予Excel建立数据库,并对纳入处方的中药、性味归经、功效进行频数统计并制作矩阵表,将矩阵表导入Spss Modeler 18、IBM Spss Statistics 26进行关联规则分析、聚类分析、决策树模型分析。结果:经药物频次分析得到了30味高频中药,包含柴胡、白芍、甘草、白术、郁金等,高频功效涉及理气药、清热药、补益药等,高频归经涉及脾经、胃经、肺经、肝经、心经、胆经等,性味以寒温、辛苦甘为主。关联规则分析得到了二项关联规则组合9个,三项关联组合6个。聚类分析得到4类药物组合,决策树模型分析显示白芍为柴胡的最佳识别中药。结论:当前治疗胆囊切除术后综合征患者仍以辨证论治为诊治根本,结合患者临床表现选方用药,以“从肝治胆,固护脾胃,行中寓补,刚柔并济”为基本原则。
Objective:To study the medication patterns of traditional Chinese medicine in the treatment of postoperative syndrome after cholecystectomy using data mining methods.Methods:Retrieve relevant literature on the treatment of adverse reactions after cholecystectomy with traditional Chinese medicine from the Chinese Science and Technology Journal Database(VIP),Chinese Academic Journal Database(Wanfang),and National Knowledge Infrastructure Database(CNKI),establish a database using electronic spreadsheet software(Excel),and conduct frequency statistics on the included traditional Chinese medicine,nature,taste,meridian,and efficacy in the prescription.Create a matrix table,and import the matrix table into Spss Modeler 18 IBM Spss Statistics 26 performs association rule analysis,cluster analysis,and decision tree model analysis.Results:Through drug frequency analysis,30 high-frequency Chinese herbal medicines were obtained,including Chaihu,Baishao,Licorice,Atractylodes macrocephala,Yujin,etc.The high-frequency effects involved regulating qi,clearing heat,tonifying drugs,etc.The high-frequency meridians involved the spleen meridian,stomach meridian,lung meridian,liver meridian,heart meridian,gallbladder meridian,etc.The main flavor was cold and warm,hard and sweet.The analysis of association rules resulted in nine combinations of binomial association rules and six combinations of trinomial association rules.Cluster analysis yielded four types of drug combinations,and decision tree model analysis showed that Baishao was the best-recognized traditional Chinese medicine for Chaihu.Conclusion:Currently,the treatment of PCS patients still relies on syndrome differentiation and treatment as the fundamental diagnosis and treatment.Based on the clinical manifestations of the patients,prescriptions,and medication are selected,with the basic principle of"treating the gallbladder from the liver,strengthening the spleen and stomach,regulating the qi mechanism,and supplementing the qi in the process".
作者
赵琳晶
王国泰
李力
常占杰
杨兴武
ZHAO Lin-jing;WANG Guo-tai;LI li(Shaanxi University of Chinese Medicine,Xianyang,Shanxi,712000,China;不详)
出处
《中西医结合肝病杂志》
CAS
2024年第7期619-623,626,共6页
Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases
基金
咸阳市中青年科技领军人才项目(No.L2022CXNLRC018)
陕西中医药大学校级科研课题(No.2023GP45)。
关键词
胆囊切除术后综合征
数据挖掘
关联规则分析
聚类分析
决策树分析
post cholecystectomy syndrome
data mining
analysis of association rules
cluster analysis
decision tree analysis
