摘要
目的观察银杏叶提取物(GBE)联合倍他司汀治疗突发性耳聋(SD)临床疗效。方法将我院120例SD患者随机分为对照组与治疗组各60例。对照组服用倍他司汀,治疗组用GBE和倍他司汀治疗。评价两种不同方法的疗效,记录SD伴随症状消失时间,测听阈,测免疫细胞(CD3^(+)、CD4^(+)和CD8^(+)比例、CD4^(+)/CD8^(+)值),血液黏度[全血高切黏度(HBV)、全血低切黏度(LBV)、血浆黏度(PV)],炎症指标[超敏C反应蛋白(hs-CRP)、白介素-6(IL-6)]的水平。结果治疗后,治疗组总有效率高于对照(P<0.05);治疗组SD伴随症状眩晕和耳鸣消失时间短于对照组(P<0.05);两组1~3 kHz范围之内的听阈、CD8^(+)比例、HBV、LBV、PV、hs-CRP、IL-6浓度低于治疗前,治疗组1~3kHz范围之内的听阈、CD8^(+)比例、HBV、LBV、PV、hsCRP、IL-6浓度低于对照组(P<0.05);两组CD3^(+)和CD4^(+)比例、CD4^(+)/CD8^(+)值高于治疗前,治疗组CD3^(+)和CD4^(+)比例、CD4^(+)/CD8^(+)值高于对照组(P<0.05)。结论GBE联合倍他司汀对SD患者的疗效较倍他司汀更优,促进眩晕和耳鸣SD症状消退,能够降低听阈,调节免疫和炎症反应,减轻血液黏度。
Objective To observe the efficacy of ginkgo biloba extract(GBE)combined with betahistine in patients with sudden deafness(SD).Methods 120 SD patients were randomly divided into control group and treatment group with 60 cases in each group.Control group was treated with betahistine,while treatment group was treated with GBE on the basis of control group.The efficacy,the time to disappearance of symptoms accompanied by SD,the hearing threshold,and the levels of immune cells(CD3^(+),CD4^(+)and CD8^(+)ratios,CD4^(+)/CD8^(+)values),blood viscosity[whole blood hypercut viscosity(HBV),whole blood low cut viscosity(LBV),plasma viscosity(PV)],and inflammatory markers[hypersensitive C-reactive protein(hs-CRP),interleukin-6(IL-6)]of the two groups were compared.Results After treatment,the total effective rate of treatment group was higher than that of control group(P<0.05);the disappearance time of SD with symptomatic vertigo and tinnitus in treatment group was shorter than that in control group(P<0.05);the concentration of hearing threshold,CD8^(+)ratio,HBV,LBV,PV,hs-CRP and IL-6 in the range of 1~3 kHz in both groups were lower than those before treatment,and were lower in observation group than control group(P<0.05);the ratio of CD3^(+)and CD4^(+)and CD4^(+)/CD8^(+)values in both groups were higher than those before treatment,and were higher in treatment group than control group(P<0.05).Conclusion GBE combined with betahistine has better efficacy than betahistine in SD patients,promoting the resolution of SD symptoms of vertigo and tinnitus,reducing hearing threshold,regulating immune and inflammatory responses,and reducing blood viscosity.
作者
张社江
吴琼芳
梁佳
王团
ZHANG She-jiang;WU Qiong-fang;LIANG Jia;WANG Tuan(Handan Ophthalmology Hospital/Handan Third Hospital,Handan 056001)
出处
《湖北中医药大学学报》
2024年第3期61-63,共3页
Journal of Hubei University of Chinese Medicine
基金
河北省邯郸市科学技术研究与发展计划项目(项目编号:21422083104)。
