摘要
目的:探究^(99m)Tc-亚甲基二膦酸盐(MDP)骨显像联合血清碱性磷酸酶(ALP)、血管内皮生长因子(VEGF)检测在乳腺癌患者骨转移评估中的诊断价值。方法:选取2020年5月—2023年2月开封市中心医院收治的82例乳腺癌患者作为研究对象,将其中出现骨转移的患者作为观察组(41例),无骨转移患者作为对照组(41例)。对比两组患者血清ALP、VEGF水平,分析82例乳腺癌患者^(99m)Tc-MDP骨显像检查结果。采用logistic回归分析乳腺癌患者是否发生骨转移与血清ALP、VEGF的相关性。采用ROC曲线分析血清ALP、VEGF单独检测及联合^(99m)Tc-MDP骨显像检测乳腺癌患者骨转移的价值。结果:观察组血清ALP、VEGF水平明显高于对照组,差异有统计学意义(t=5.471、28.253,P<0.05)。以病理检查作为金标准,^(99m)Tc-MDP骨显像诊断乳腺癌患者骨转移的灵敏度为80.49%,特异度为63.41%,准确率为71.95%。logistic回归分析结果显示,血清ALP、VEGF与乳腺癌患者发生骨转移暗恋具有相关性,差异有统计学意义(OR=6.759、1.483,P<0.05)。血清ALP、VEGF单独检测及联合^(99m)Tc-MDP骨显像检测在预测乳腺癌患者骨转移的ROC曲线下面积(AUC)分别为0.668、0.701、0.843,联合检测的AUC优于血清ALP、VEGF单独检测,差异有统计学意义(P<0.05)。结论:血清ALP、VEGF与乳腺癌患者是否发生骨转移关系密切。^(99m)Tc-MDP、血清ALP、VEGF检测在乳腺癌患者骨转移中均具有较好的诊断价值,联合检测能有效提高诊断效能。
Objective:To explore the diagnostic value of^(99m)Tc MDP bone imaging combined with serum Alkaline phosphatase(ALP)and Vascular endothelial growth factor(VEGF)in the assessment of bone metastasis of breast cancer.Methods:The clinical data of 82 breast cancer patients admitted to the hospital from May 2020 to February 2023 were retrospectively analyzed.Among them,there were 41 patients with bone metastasis(observation group)and 41 patients without bone metastasis(control group).The serum ALP and VEGF levels between the two groups of patients were compared.The results of^(99m)Tc MDP bone imaging in 82 patients with breast cancer were analyzed.Logistic regression analysis was used to analyze the correlation between bone metastasis,and serum ALP and VEGF in patients with breast cancer.ROC was used to analyze the value of serum ALP and VEGF alone and^(99m)Tc-MDP bone imaging in detecting bone metastasis of breast cancer.Results:Serum ALP and VEGF levels in observation group were significantly higher than those in control group,and the differences were statistically significant(t=5.471,28.253;P<0.05).Through using pathological examination as the gold standard,the sensitivity of^(99m)Tc-MDP bone imaging was 80.49%,specificity was 63.41%and accuracy was 71.95%in the diagnosis of adenocarcinoma bone metastasis.Logistic regression analysis showed that serum ALP and VEGF were correlated with bone metastasis in breast cancer patients(OR=6.759,1.483;P<0.05).The area under ROC curve(AUC)of serum ALP and VEGF alone and combined^(99m)Tc-MDP bone imaging were 0.668,0.701 and 0.843,respectively.AUC of combined detection was superior to that of serum ALP and VEGF alone,with statistically significant difference(P<0.05).Conclusion:Serum ALP and VEGF are closely related to bone metastasis in breast cancer patients.The detection of^(99m)Tc MDP,serum ALP and serum VEGF has good value in bone metastasis of breast cancer,and the combined detection can effectively improve the diagnostic efficiency.
作者
刘姗姗
王永宁
Liu Shanshan;Wang Yongning(Nuclear Medicine,Kaifeng Central Hospital,Kaifeng,Henan,475001,China)
出处
《黑龙江医学》
2024年第14期1729-1731,共3页
Heilongjiang Medical Journal
