摘要
药物晶型的差异导致药物溶解度和稳定性不同,进而影响药物的临床疗效及生物利用度。因此,近年来药物晶型越来越受到研究者们的重视。该文通过查阅并整理相关文献,从药物晶型的影响因素、药物晶型的识别与控制、药物晶型评价方法及应用等方面对近年来药物结晶理论研究进展进行概括总结,旨在为药物晶型的控制、工艺筛选等提供参考。
The difference in the crystal form of the drug leads to different solubility and stability,affecting drug’s the clinical efficacy and bioavailability.Therefore,in recent years,drug crystal forms have received more and more attention from researchers.By reviewing and sorting out relevant literature,this paper summarizes the research progress of drug crystallization theory in recent years from the aspects of influencing factors of drug crystal form,identification and control of drug crystal form,drug crystal form evaluation methods,and applications,aiming to provide a reference for drug crystal form control and process screening.
作者
吕春艳
厚晓庆
崔闻宇
张文君
王文倩
韩锐
LYU Chunyan;HOU Xiaoqing;CUI Wenyu;ZHANG Wenjun;WANG Wenqian;HAN Rui(School of Pharmaceutical Science,Harbin University of Commerce,Harbin 150076,China;Engineering Research Center of Natural Anti-cancer Drugs,Ministry of Education,Harbin 150076,China;Heilongjiang Key Laboratory of Preventive and Therapeutic Drug Research of Senile Diseases,Harbin 150076,China)
出处
《医药导报》
CAS
北大核心
2024年第8期1296-1302,共7页
Herald of Medicine
基金
黑龙江省教育厅青年后备人才专项计划项目(2019CX41)
2020年度黑龙江省博士后科研启动金(LBH-Q20102)
哈尔滨商业大学博士科研启动基金项目(13DL023)。
关键词
药物晶型
在线原位监测
结晶动力学
结晶工艺
Drug crystal
Online in-situ monitoring technology
Crystallization kinetics
Crystallization process
