摘要
环状RNA(circular RNA,circRNA)是一类不具有5′末端帽子和3′末端多聚腺苷酸尾巴并以共价键形成封闭环状结构的内源性非编码RNA(non-coding RNA,ncRNA)。由于circRNA结构的特殊性,其对RNA外切酶R(ribonucleic acid exonuclease R,RNaseR)具有高度抵抗性,因此在细胞质中的分布相当丰富。高通量测序和生物信息学方法的不断发展揭示了circRNA具有高度保守性、稳定性、疾病特异性和组织特异性的特点,使其在临床早期诊断中具有作为生物标志物的潜能。研究已证实circRNA在女性生殖系统中与卵子发生、卵巢功能不全、卵巢相关性疾病以及在男性生殖系统中与精子发生、睾丸发育之间相互作用,有望成为多种生殖系统疾病新的诊断和治疗靶点。综述circRNA在生殖系统发育中的生物学功能及其调控作用。
Circular RNAs(circRNAs)are a class of endogenous non-coding RNA(ncRNA)without 5′N7-methylguanosine caps and 3′polyadenylated tails,forming a close loop structure with covalent bonds.Due to the specificity of circRNAs structure,it is highly resistant to ribonucleic acid exonuclease R(RNaseR)and is therefore quite abundant in the cytoplasm.The continuous development of high-throughput sequencing and bioinformatics methods has revealed that circRNAs are highly conserved,stable,disease-specific,and tissue-specific,giving them potential as biomarkers in early clinical diagnosis.Studies have demonstrated that circRNAs interact with oogenesis,ovarian aging,and ovary-related diseases in the female reproductive system,and with spermatogenesis and testicular development in the male reproductive system.CircRNAs are expected to be new diagnostic and therapeutic targets for a variety of reproductive disease.In the paper,we will focus on the biological functions and regulatory roles of circRNAs in reproductive system.
作者
焦梦文
张月文
王玲
莫少康(审校)
JIAO Meng-wen;ZHANG Yue-wen;WANG Ling;MO Shao-kang(School of Public Health,Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China;Center for Reproductive Medicine,The 940th Hospital of Joint Logistic Support Force of the People′s Liberation Army,Lanzhou 730050,China)
出处
《国际生殖健康／计划生育杂志》
CAS
2024年第4期322-327,共6页
Journal of International Reproductive Health/Family Planning
基金
甘肃省科技计划项目(20JR5RA592)。
