摘要
功能性消化不良(functional dyspepsia,FD)是临床常见的功能性胃肠疾病,中医学认为其基础病机为脾虚气滞,胃失和降,中焦气机升降失调。小肠作为脾升胃降的中心环节,小肠受盛化物、泌别清浊的功能与脾升清、胃降浊的过程密切相关。若小肠功能失常,则影响脾胃气机升降,中焦气机不利,最终导致FD的发生。而中医学对于小肠功能的认识是在人体解剖学的基础上结合临床实践产生的,小肠功能的实现亦需要依靠相应的人体解剖学组织。当西医学十二指肠出现异常改变,如十二指肠内脏高敏感及肠黏膜屏障受损时,中医小肠受盛化物、泌别清浊的生理功能亦会受到影响,进而容易诱发或导致FD。中医药可通过调节十二指肠高敏感和肠黏膜屏障功能对FD具有积极的治疗作用。因此,本文基于胃、小肠、脾之间的联系探讨中医小肠在FD发病中的作用,为FD的中医药防治提供了新的思路和理论依据。
Functional dyspepsia(FD)is a common clinical functional gastrointestinal disease.Traditional Chinese medicine(TCM)believes that its basic pathogenesis is spleen deficiency and Qi stagnation,failure of stomach Qi to a descendand disturbance in ascending and descending of middle jiao.The small intestine is the central link of the spleen ascending and the stomach descending.The functions of the small intestine in"containing and digesting"and"separating the clear from the turbid"are closely associated with the process of the spleen raising the clear and the stomach lowering the turbid.If the functions of the small intestine are abnormal,it will affect the rise and fall of the spleen and stomach Qi,and the middle jiao is unfavorable,which will eventually lead to the occurrence of FD.The understanding of small intestine function in TCM is based on human anatomy combined with clinical practice,and the function of the small intestine is also dependent on the organization of the human anatomy.Thus,when there are abnormal changes in the duodenum in Western medicine,such as when the duodenal viscera are hypersensitive and the intestinal mucosal barrier is impaired,the physiological functions of the small intestine"containing and digesting"and"separating the clear from the turbid"in Chinese medicine will also be affected,which in turn will easily induce or lead to FD.TCM can have positive therapeutic effects on FD by regulating duodenal hypersensitivity and intestinal mucosal barrier function.Therefore,exploring the role of the small intestine in the pathogenesis of FD based on the link between the stomach,small intestine,and spleen provides a new idea and theoretical basis for the prevention and treatment of FD.
作者
杨竹青
王晓鸽
郭敏
刘镇亚
姚翠翠
王璐
李合国
YANG Zhuqing;WANG Xiaoge;GUO Min;LIU Zhenya;YAO Cuicui;WANG Lu;LI Heguo(Department of Spleen,Stomach,Hepatobiliary Diseases,the First Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou,450003,China;The First Clinical College of Henan University of Traditional Chinese Medicine)
出处
《中国中西医结合消化杂志》
CAS
2024年第7期617-622,共6页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
基金
国家自然科学基金项目(No:82104776)
国家中医药治疗难治性胃肠病的传承与创新团队项目(No:ZYYCXTD-C-202010)。
关键词
功能性消化不良
十二指肠
小肠
脾
胃
发病机制
functional dyspepsia
duodenum
small intestine
spleen
stomach
pathogenesis
