摘要
目的 利用功能性近红外光谱成像(functional near-infrared spectroscopy, fNIRS)技术探究健康成年人主动屈肘、被动屈肘和想象屈肘运动脑激活的特点。方法 选取30名健康大学生为被试者,男女各15例,年龄(21.22±1.42)岁,选择右手主动、被动和想象屈肘任务作为刺激模式,采用近红外光谱脑功能成像系统实时采集被试者3种不同运动模式下脑功能区氧合血红蛋白(Oxyhemoglobin, HbO2)水平作为脑激活的特征值,并以静息态(resting state, RS)的HbO2水平为基线值,比较3种运动模式下脑激活的特点。结果 非参数检验结果表明,不同运动模式下,右侧初级运动皮层(H=13.309,P=0.004),右侧前额叶前部皮层(H=20.30,P<0.001),右侧背外侧前额叶皮层(H=12.194,P=0.007),左侧初级体感皮层(H=12.642,P=0.005),左侧初级运动皮层(H=20.03,P<0.001),左侧前额叶前部皮层(H=18.187,P<0.001),左侧背外侧前额叶皮层(H=13.379,P=0.004)的HbO2水平比较差异有统计学意义;而其右侧初级体感皮层(H=4.284,P=0.232),右侧前运动区和辅助运动皮层(H=4.201,P=0.241),左侧前运动区和辅助运动皮层(H=8.793,P=0.052)HbO2水平比较差异无统计学意义。结论 不同运动模式下存在特定的脑功能区激活,其激活程度既有相似性又有差异性,主动运动和被动运动任务下的脑激活区最类似。
Objective To investigate the characteristics of brain activation in active elbow flexion,passive elbow flexion and imaginary elbow flexion in healthy adults using functional near-infrared spectroscopy(fNIRS).Methods 30 healthy college students were selected as subjects,15 of each gender,aged(21.22±1.42)years old.Active,passive and imaginary elbow flexion tasks on the right hand were selected as stimulation paradigms,and fNIRS was used to collect real-time oxyhemoglobin(HbO_2)concentrations in brain functional areas under three different motor paradigms as the characteristic values of brain activation.The resting state HbO_2 concentration was used as the baseline value to compare the characteristics of brain activation under the three different motor paradigms.Results The nonparametric test results showed that under different motor paradigms,there were statistically significant differences in HbO_2 levels in the right primary motor cortex(H=13.309,P=0.004),the right prefrontal anterior cortex(H=20.30,P<0.001),the right dorsolateral prefrontal cortex(H=12.194,P=0.007),the left primary somatosensory cortex(H=12.642,P=0.005),the left primary motor cortex(H=20.03,P<0.001),left anterior prefrontal cortex(H=18.187,P<0.001),and left dorsolateral prefrontal cortex(H=13.379,P=0.004);however,there were no statistically significant differences in the right primary somatosensory cortex(H=4.284,P=0.232),the right anterior motor cortex and auxiliary motor cortex(H=4.201,P=0.241),and the left anterior motor cortex and auxiliary motor cortex(H=8.793,P=0.052).Conclusion There are specific functional brain regions activated under different motor paradigms,with both similarities and differences in the degree of activation,with the most similar brain activated regions in active and passive movement tasks.
作者
喻多多
魏聪惠
罗军
YU Duo-duo;WEI Cong-hui;LUO Jun(Department of Rehabilitation Medicine,the Second Affiliated Hospital of Nanchang University,Nanchang 330006,China;School of Clinical Medicine,Nanchang Medical College,Nanchang 330036,China)
出处
《南昌大学学报（医学版）》
2024年第3期46-51,共6页
Journal of Nanchang University：Medical Sciences
基金
国家重点研发计划项目(2020YFC2005800)
江西省教育厅科学技术研究项目(GJJ2189300)。
关键词
功能性近红外光谱成像技术
主动运动
被动运动
想象运动
氧合血红蛋白
脑功能区
脑激活
functional near-infrared spectroscopy
active movement
passive movement
imaginary movement
oxyhemoglobin
functional brain region
brain activation
