摘要
目的探讨磷酸甘油酸激酶1(PGK1)、烯醇化酶1(ENO1)在子宫内膜癌(EC)中的表达及临床意义。方法收集41例EC患者的EC组织、癌旁组织及10例子宫肌瘤或卵巢良性囊肿患者的正常子宫内膜组织,采用免疫组化法检测PGK1、ENO1表达情况。比较EC组织、癌旁组织、正常子宫内膜组织中PGK1、ENO1表达情况,比较不同临床特征EC患者EC组织中PGK1、ENO1表达情况。结果EC组织中PGK1阳性表达率高于癌旁组织,ENO1阳性表达率高于癌旁组织和正常子宫内膜组织,差异均有统计学意义(P﹤0.05)。年龄≥50岁EC患者EC组织中PGK1阳性表达率高于年龄﹤50岁患者,差异有统计学意义(P﹤0.05)。结论PGK1、ENO1在EC组织中的阳性表达率均较高,可能与EC的发生有关,靶向作用PGK1、ENO1可能给EC患者的治疗带来新的希望。
Objective To explore the expression and clinical significance of phosphoglycerate kinase 1(PGK1)and enolase 1(ENO1)in endometrial carcinoma(EC).Method The EC tissues and paracancer tissues of 41 patients with EC and normal endometrial tissues of 10 patients with uterine fibroids or benign ovarian cysts were collected.The expressions of PGK1 and ENO1 were detected by immunohistochemistry.The expressions of PGK1 and ENO1 in EC tissues,paracancer tissues and normal endometrial tissues were compared,and the expressions of PGK1 and ENO1 in EC tissues of EC patients with different clinical characteristics were also compared.Result The positive expression rate of PGK1in EC tissues was higher than that in paracancer tissues,and the positive expression rate of ENO1 was higher than that in paracancer tissues and normal endometrial tissues,and the differences were statistically significant(P<0.05).The positive expression rate of PGK1 in EC tissues of EC patients≥50 years old was higher than that of patients<50 years old,and the difference was statistically significant(P<0.05).Conclusion The positive expression rates of PGK1 and ENO1 are high in EC tissues,and may be related to the occurrence of EC.Targeting PGK1 and ENO1 may bring new hope for the treatment of EC patients.
作者
康燕
黄华民
KANG Yan;HUANG Huamin(Second Department of Gynecology,Qinghai Red Cross Hospital,Xining 810000,Qinghai,China)
出处
《癌症进展》
2024年第11期1188-1191,共4页
Oncology Progress
基金
青海省卫生健康系统指导性计划课题(2022-wjzdx-85、2019-wjzdx-74)
青海省创新平台建设专项(2024-0405-SFC-0004)。
