摘要
目的 探究胸腔镜微创手术对肺癌患者血清肿瘤标志物及T淋巴细胞亚群的影响。方法 将104例肺癌患者按不同手术治疗方案分成2组,每组52例。对照组予以传统开胸手术治疗,研究组予以胸腔镜微创手术治疗。对比2组手术相关指标和血清肿瘤标志物、T淋巴细胞亚群指标水平,并开展安全性评估。结果 研究组的手术时间和术中失血量、术后恢复时间均低于对照组,差异有统计学意义(P<0.05);2组淋巴结清扫数对比,差异无统计学意义(P>0.05)。术后24 h, 2组血清癌胚抗原(CEA)和糖类抗原125(CA125)水平均较术前低(P<0.05),但2组间血清CEA、CA125水平对比,差异无统计学意义(P>0.05)。术后d 7,2组CD3^(+)、CD4^(+)、CD8^(+)及CD4^(+)/CD8^(+)水平均较本组术前低,但研究组高于对照组,差异有统计学意义(P<0.05)。研究组治疗安全性优于对照组,差异有统计学意义(P<0.05)。结论 胸腔镜微创手术治疗肺癌优势明显,能降低血清肿瘤标志物含量,减轻手术治疗对T淋巴细胞亚群的影响,且并发症少,安全性更高,患者易接受。
Objective To investigate the effects of thoracoscopic minimally invasive surgery on serum tumor markers and T lymphocyte subsets in lung cancer patients.Methods 104 lung cancer patients were divided into 2 groups according to different surgical treatment plans,with 52 cases in each group.The control group received traditional open chest surgery treatment,while the study group received thoracoscopic minimally invasive surgery treatment.Compare the levels of surgical related indicators,serum tumor markers,and T lymphocyte subsets between the 2 groups,and conduct safety assessments.Results The surgical time,intraoperative blood loss,and postoperative recovery time of the study group were lower than those of the control group,and the differences were statistically significant(P<0.05);There was no statistically significant difference in lymph node dissection between the 2 groups(P>0.05).24 hours after surgery,the serum levels of carcinoembryonic antigen(CEA)and carbohydrate antigen 125(CA125)in both groups were lower than before surgery(P<0.05),but there was no statistically significant difference in serum CEA and CA125 levels between the 2 groups(P>0.05).7 days after surgery,the levels of CD3^(+),CD4^(+),CD8^(+),and CD4^(+)/CD8^(+)in both groups were lower than before surgery,but the study group was higher than the control group,with statistical significance(P<0.05).The treatment safety of the research group was better than that of the control group,and the difference was statistically significant(P<0.05).Conclusion Thoracoscopic minimally invasive surgery has significant advantages in treating lung cancer,reducing serum tumor marker levels and alleviating the impact of surgical treatment on T lymphocyte subsets with fewer complications,higher safety,and is easily accepted by patients.
作者
冯帅兵
师智勇
刘守知
彭要要
孟凡若
FENG Shuaibing;SHI Zhiyong;LIU Shouzhi(Pingmei Shenma Medical Group General Hospital,Pingdingshan,467000)
出处
《实用癌症杂志》
2024年第7期1179-1182,共4页
The Practical Journal of Cancer
关键词
肺癌
胸腔镜微创手术
血清肿瘤标志物
T淋巴细胞亚群
Lung cancer
Thoracoscopic minimally invasive surgery
Serum tumor markers
T lymphocyte subpopulation
