摘要
目的:探讨糖链抗原50(CA50)、糖链抗原724(CA724)及细胞角蛋白19的可溶性片段(CYFRA211)在结直肠癌诊断中的应用价值。方法:选取2022年3月至2023年4月我院收治的72例结直肠癌患者作为结直肠癌组,另选同期健康体检者30人作为对照组。检测2组受检者血清CA50、CA724及CYFRA211表达水平,进行对比分析;比较不同临床分期、分化程度及淋巴结转移情况结直肠癌患者血清CA50、CA724及CYFRA211表达水平;绘制ROC曲线分析CA50、CA724、CYFRA211单项检测与联合检测对结直肠癌的诊断效能。结果:结直肠癌组CA50、CA724、CYFRA211表达水平及阳性表达率均高于对照组,P<0.001。结直肠癌患者CA50、CA724、CYFRA211表达水平:临床分期Ⅳ期>Ⅲ期>Ⅱ期>Ⅰ期(P<0.001),低分化>中分化>高分化(P<0.001),淋巴结转移者>无淋巴结转移者(P<0.001)。CA50诊断结直肠癌的截断值为19.51 IU/mL,AUC为0.778;CA724诊断结直肠癌的截断值为9.73 IU/mL,AUC为0.787;CYFRA211诊断结直肠癌的截断值为12.00 ng/mL,AUC为0.819;三者联合诊断结直肠癌的AUC为0.944,敏感度与特异度分别为87.50%和93.33%,其诊断效能均较CA50、CA724、CYFRA211单一检测高(P<0.001)。结论:结直肠癌患者血清CA50、CA724、CYFRA211均呈高表达,三者联合检测有助于提高临床结直肠癌的早期诊断准确率,辅助其临床分期、分化程度及淋巴结转移情况判定。
Objective To investigate the diagnostic value of carbohydrate antigen 50(CA50),carbohydrate antigen 724(CA724)and soluble fragment of cytokeratin 19(CYFRA211)in colorectal cancer.Methods Total 72 patients with colorectal cancer admitted to our hospital from March 2022 to April 2023 were selected as the colorectal cancer group,and 3o healthy subjects were selected as the control group during the same period.The expression levels of serum CA50,CA724 and CYFRA211 in both groups were detected and compared.The expression levels of serum CA50,CA724 and CYFRA21l in colorectal cancer patients with different clinical stage,differentiation degree and lymph node metastasis were compared.ROC curve was drawn to analyze the diagnostic efficacy of single detection and combined detection of CA50,CA724 and CYFRA211 in colorectal cancer.Results The expression levels and positive rates of CA50,CA724 and CYFRA211 in the colorectal cancer group were higher than those in the control group(P<0.001).The expression levels of CA50,CA724 and CYFRA211 in colorectal cancer patients were as following:stage IV>stage II>stage II>stage I(P<0.001),low differentiation>medium differentiation>high differentiation(P<0.001),and lymph node metastasis>no lymph node metastasis(P<0.001).The cutoff value of CA50 in the diagnosis of colorectal cancer was 19.51 IU/mL and the AUC was 0.778.The cutoff value of CA724 in the diagnosis of colorectal cancer was 9.73 IU/mL and the AUC was 0.787.The cut-off value of CYFRA211 in the diagnosis of colorectal cancer were 12.00 ng/mL and the AUC was 0.819.The AUC,sensitivity and specificity of the combined detection were 0.944,87.50%and 93.33%,respectively.The diagnostic efficacy of the combined detection was higher than that of simple CA50,CA724 and CYFRA211(P<0.001).Conclusion Serum CA50,CA724 and CYFRA211 are highly expressed in patients with colorectal cancer.The combined detection is helpful to improve the accuracy of early diagnosis of clinical colorectal cancer,and assists in the evaluation of clinical stage,diffe
作者
彭慧斌
韩晓东
高小盼
PENG Hui-bin;HAN Xiao-dong;GAO Xiao-pan(Department of Clinical Laboratory,Anyang Cancer Hospital,Anyang,Henan 455000;The Fourth Department of Surgery,Anyang Cancer Hospital,Anyang,Henan 455000;Department of Ultrasound,Anyang Cancer Hospital,Anyang,Henan 455000)
出处
《中国肛肠病杂志》
2024年第5期33-35,共3页
Chinese Journal of Coloproctology
关键词
结直肠癌
糖链抗原50
糖链抗原724
细胞角蛋白19的可溶性片段
诊断
Colorectal cancer
Carbohydrate antigen 50(CA50)
Carbohydrate antigen 724(CA724)
Soluble fragment of cytokeratin 19(CYFRA211)
Diagnosis
