摘要
目的探讨超时间窗机械取栓联合动脉溶栓治疗急性脑梗死的疗效。方法选取2017年10月至2019年6月荆州市第三人民医院需行超时间窗溶栓治疗的90例急性脑梗死患者作为研究对象,按照治疗方式不同分为研究组与对照组,各45例。对照组给予动脉溶栓治疗,研究组在对照组基础上给予机械取栓治疗。比较两组临床疗效,凝血指标[凝血酶原时间(PT)、纤维蛋白原(Fg)、凝血酶时间(TT)],血清超敏C反应蛋白(hs-CRP)、氧化型低密度脂蛋白(Ox-LDL)、同型半胱氨酸(Hcy)水平,美国国立卫生研究院卒中量表(NIHSS)评分、欧洲卒中量表(ESS)评分及预后情况。结果研究组治疗总有效率为93.33%,高于对照组的73.33%,差异有统计学意义(P<0.05)。治疗后,研究组PT长于对照组,TT短于对照组,Fg、hs-CRP、Ox-LDL、Hcy水平均低于对照组,差异有统计学意义(P<0.05);治疗后,研究组ESS评分高于对照组,NIHSS评分低于对照组,差异有统计学意义(P<0.05)。研究组血管再通率、≤30%残余狭窄率均高于对照组,颅内出血率低于对照组,差异有统计学意义(P<0.05)。结论超时间窗机械取栓联合动脉溶栓治疗急性脑梗死疗效显著,可有效调节凝血指标,降低炎症反应及脂蛋白水平,提高血管再通率,减轻患者病情严重程度,改善预后。
Objective To investigate the efficacy of over-time-window mechanical thrombectomy combined with arterial thrombolysis in the treatment of acute cerebral infarction.Methods 90 patients requiring over-time-window thrombolytic therapy from Jingzhou Third People's Hospi-tal from October 2017 to June 2019 were selected as the research subjects,and they were divided into the study group and the control group according to different treatment methods,with 45 cases in each group.The control group was given arterial thrombolysis,and the study group was given me-chanical thrombectomy on the basis of the control group,the clinical efficacy,coagulation indicators(coagulation index[PT],thrombin time[TT],fi-brinogen[Fg]),and the levels of serum hypersensitive C-reactive protein(hs-CRP),oxidized low density lipoprotein(Ox-LDL),homocysteine(Hcy),National Institutes of Health stroke scale(NIHSS)score,European stroke scale(ESS)score and prognosis were compared between the two groups.Results The total effective rate in the study group was 93.33%,which was higher than 73.33%in the control group,and the difference was statisti-cally significant(P<0.05).After treatment,the PT in the study group was longer than that in the control group,TT was shorter than that in the control group,levels of Fg,hs-CRP,Ox-LDL and Hcy in the study group were lower than those in the control group,and the differences were statistically sig-nificant(P<0.05).After treatment,the ESS score in the study group was higher than that in the control group,NIHSS score was lower than that in the control group,and the differences were statistically significant(P<0.05).The rate of vascular revascularization and≤30%residual stenosis in the study group was higher than that in the control group,and the rate of intracranial hemorrhage was lower than that in the control group,the differences were statistically significant(P<0.05).Conclusions Over-time-window mechanical thrombectomy combined with arterial thrombolysis is effective in the treatment of acute cerebral infarctio
作者
卢鸿
代津津
韩桃
LU Hong;DAI Jinjin;HAN Tao(Department of Neurology,the Third People's Hospital of Jingzhou,Jingzhou,Hubei,434000,China)
出处
《当代医学》
2024年第6期56-59,共4页
Contemporary Medicine
关键词
超时间窗机械取栓
动脉溶栓
急性脑梗死
血管再通率
凝血功能
纤维蛋白原
Over-time-window mechanical thrombectomy
Arterial thrombolysis
Acute cerebral infarction
Recanalization rate
Coagulation function
Fibrinogen
