摘要
创伤性中枢神经系统损伤后,肠道菌群变化扰乱了脑-肠轴的平衡,引发机体异常的免疫炎症级联反应,加重继发性损伤。最新研究发现,通过免疫治疗减少创伤性中枢神经系统损伤引起的神经炎症,从而促进神经功能恢复是一种有前景的治疗方案,而肠道菌群可能是治疗靶点之一。文章主要就肠道菌群及其代谢产物色氨酸、短链脂肪酸、脂多糖、肽聚糖通过调节淋巴细胞、神经胶质细胞调控创伤后的免疫应答,影响神经炎症的作用机制进行综述,并对该领域临床研究现状进行总结与展望,以期为该类疾病开发新的治疗靶点和康复策略。
After traumatic central nervous system injury,intestinal flora changes disturb the balance of brain-gut axis,triggering abnormal immune inflammatory cascade and aggravating secondary injury.Recent research has found that reducing neuroinflammation caused by traumatic central nervous system injury through immunotherapy,thereby promoting neurological function recovery,is a promising treatment option,and gut flora may be one of the therapeutic targets.This article mainly reviews the mechanism by which intestinal flora and its metabolites tryptophan,short-chain fatty acids,lipopolysaccharides and peptidoglycans regulate the immune response after trauma and affect neuroinflammation by regulating lymphocytes and glial cells,and summarizes and prospects the current clinical research status in this field,with a view to developing new therapeutic targets and rehabilitation strategies for these diseases.
作者
尚文雅
黄靖(综述)
任亚锋(审校)
SHANG Wenya;HUANG Jing;REN Yafeng(Rehabilitation School of Henan University of Chinese Medicine,Zhengzhou 450000,Henan,China;Rehabilitation Center,The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,Henan,China)
出处
《医学研究与战创伤救治》
CAS
北大核心
2024年第4期427-432,共6页
Journal of Medical Research & Combat Trauma Care
基金
河南省中医药科学研究专项基金(2022JDZX015,2021JDZY022)
河南省“双一流”创建学科中医学科学研究专项基金(HSRP-DFCTCM-2023-1-25)。
关键词
创伤性脑损伤
脊髓损伤
肠道菌群
免疫
神经炎症
traumatic brain injury
spinal cord injury
gut microbiota
immunity
neuroinflammation
