摘要
目的探讨慢性肾脏病(CKD)合并肺部感染的病原菌分布及危险因素。方法回顾性分析2021年10月—2022年9月东南大学附属中大医院江北院区肾内科收治的310例CKD患者的临床资料,根据是否发生肺部感染分为感染组104例和未感染组206例。统计感染组的病原菌分布情况;采用单因素和多因素Logistic回归分析CKD患者发生肺部感染的危险因素。结果肺部感染组共分离出90株病原菌,主要为革兰氏阴性菌(66.67%),最常见的细菌为肺炎克雷伯菌(23.33%);Logistic分析结果显示,年龄≥65岁、合并胸腔积液、基础疾病数量、侵入性操作、合并低蛋白血症、贫血均为影响CKD患者并发肺部感染的危险因素(P<0.05)。结论CKD合并肺部感染患者的病原菌以革兰氏阴性菌为主,对于存在年龄≥65岁、合并基础疾病数量越多、合并胸腔积液、低蛋白血症,贫血及有侵入性操作等危险因素的CKD患者需要提高重视,可采取针对性的措施预防肺部感染发生。
Objective To analyze the pathogenic bacteria characteristics and risk factors of chronic kidney disease(CKD)complicated with pulmonary infection.Methods The clinical data of 310 patients with CKD admitted to the Department of Nephrology,Jiangbei Hospital,Zhongda Hospital Affiliated to Southeast University from October 2021 to September 2022 were retrospectively analyzed.According to the occurrence of lung infection,104 cases were divided into infection group and 206 cases were not infected group.The distribution of pathogenic bacteria in pulmonary infection group was analyzed;Univariate analysis and multivariate Logistic regression analysis was used to screen the independent risk factors affecting the occurrence of pulmonary infection in patients with CKD.Results A total of 90 strains of pathogenic bacteria were isolated from pulmonary infection group,among which Gram-negative bacteria accounted for 66.67%(mainly Klebsiella pneumoniae 23.33%);Logistic regression analysis showed that age≥65 years old,pleural effusion,number of underlying diseases,invasive procedures,hypoproteinemia and anemia were all risk factors for pulmonary infection in CKD patients(P<0.05).Conclusion The pathogenic bacteria in patients with CKD complicated with lung infection are mainly Gram-negative bacteria.Attention should be paid to patients with CKD who are older or older than 65 years old,have more underlying diseases,have pleural effusion,hypoproteinemia,anemia and have invasive procedures and other risk factors,and targeted measures can be taken to prevent the occurrence of lung infection.
作者
李妮妮
陆瑾
蒙钟经
刘中秋
展冠军
LI Nini;LU Jin;MENG Zhongjing;LIU Zhongqiu;ZHAN Guanjun(Department of Pharmacy,Zhongda Hospital Affiliated to Southeast University Jiangbei,Nanjing 210048,China)
出处
《西部医学》
2024年第7期1012-1015,共4页
Medical Journal of West China
基金
南京药学会-常州四药医院药学科研基金项目(2022YX025)。
关键词
慢性肾脏病
肺部感染
病原菌分布
危险因素
Chronic kidney disease
Lung infection
Etiological distribution
Risk factor
