摘要
目的:探讨糖皮质激素联合抗病毒治疗对青少年病毒性角膜内皮炎患者视力恢复及角膜内皮形态的影响。方法:选择恩施爱尔眼科医院2021年2月—2024年2月收治的126例青少年病毒性角膜内皮炎患者为研究对象,依据数字盲抽法分入常规组(63例)和观察组(63例)。常规组行抗病毒治疗,观察组行抗病毒联合糖皮质激素治疗。比较两组临床疗效、视力恢复情况及角膜内皮形态情况。结果:观察组总有效率为95.24%,高于常规组的79.37%(P<0.05)。同时,观察组治疗后视力高于常规组,角膜厚度、角膜细胞计数、细胞多样性变异率优于常规组(P<0.05)。结论:糖皮质激素联合抗病毒治疗可以加快青少年病毒性角膜内皮炎患者的视力恢复,改善角膜内皮形态,临床效果理想。
Objective:To investigate the effects of glucocorticoid combined with antiviral therapy on visual recovery and corneal endothelial morphology in adolescent patients with viral corneal endodermatitis.Methods:A total of 126 adolescent patients with viral corneal endotheliitis admitted to Enshi Aier Eye Hospital from February 2021 to February 2024 were selected as the research objects,and they were divided into routine group(63 patients)and observation group(63 patients)according to digital blind sampling method.The conventional group was treated with antiviral therapy,and the observation group was treated with antiviral therapy combined with glucocorticoid therapy.The clinical efficacy,visual acuity recovery and corneal endothelial morphology were compared between the two groups.Results:The total effective rate of the observation group was 95.24%,which was higher than 79.37%of the conventional group(P<0.05).At the same time,the visual acuity of the observation group after treatment was higher than that of the conventional group,and the corneal thickness,corneal cell count and cell diversity variation rate were better than those of the conventional group(P<0.05).Conclusion:Glucocorticoid combined with antiviral therapy can accelerate vision recovery and improve corneal endothelial morphology in adolescent patients with viral keratodermatitis,and the clinical effect is ideal.
作者
林梦
沈梅晓
LIN Meng;SHEN Meixiao(Ophthalmology Hospital of Wenzhou Medical University,Wenzhou 325000,Zhejiang,China;Enshi Aier Eye Hospital,Enshi 445000,Hubei,China)
出处
《中国药物滥用防治杂志》
CAS
2024年第5期891-894,共4页
Chinese Journal of Drug Abuse Prevention and Treatment
基金
2020年湖北省医疗卫生领域科技计划项目(重点项目)(编号:2020YL27)。
关键词
青少年
病毒性角膜内皮炎
抗病毒治疗
糖皮质激素
角膜内皮形态
视力
Adolescent
Viral corneal endotheliitis
Antiviral therapy
Corticosteroids
Corneal endothelial morphology
Visual acuity
