摘要
目的探讨饮水量对胚胎移植患者术前膀胱充盈时间的影响。方法收集2023年2月至6月期间于广东省妇幼保健院生殖健康与不孕症科拟行体外受精-胚胎移植的患者189例。运用随机数字表将患者随机分为A、B、C 3组,各组样本量依次为61例、64例和64例,分别给予术前饮水300 mL、500 mL和700 mL。于饮水后45 min开始,每15 min进行腹部超声监测,共1~5次,记录膀胱充盈时间和膀胱容量。采用Kaplan-Meier法比较3组患者膀胱充盈时间的差异,并采用多因素Cox回归分析膀胱充盈时间的影响因素。结果A、B、C组患者饮水后105 min累积膀胱充盈率分别为57.4%(35/61)、90.6%(58/64)和98.4%(63/64),膀胱充盈中位生存时间(95%CI)为105.0(89.9~120.1)min、60.0(55.4~64.7)min和60.0(55.4~64.6)min。Kaplan-Meier成对比较结果显示,A组膀胱充盈时间长于B组和C组(均P<0.001),B组膀胱充盈中位生存时间与C组之间差异无统计学意义(P>0.05)。按年龄分层分析结果显示,低龄层(<35岁)患者膀胱充盈中位生存时间A组[90.0(75.2~104.8)min]长于B组[60.0(55.8~64.2)min,P<0.001]和C组[60.0(55.1~64.8)min,P<0.001],B组与C组之间差异无统计学意义(P>0.05);高龄层(≥35岁)患者膀胱充盈中位生存时间A组与B组之间差异无统计学意义(P>0.05),C组[60.0(59.1~70.9)min]短于A组(105.0 min,P<0.001)和B组[75.0(64.3~85.7)min,P=0.027]。多因素Cox回归分析结果显示,以A组为参考类别,B、C组的风险比(hazard ratio,HR)分别为2.71、3.23,95%CI分别为1.78~4.21、2.10~4.96,均P<0.001;高龄HR为0.69,95%CI为0.49~0.99,P=0.044。结论饮水量和年龄为胚胎移植患者膀胱充盈时间的独立影响因素。胚胎移植患者宜术前75 min饮水500 mL,并对高龄患者适当增加饮水量或延长饮水后膀胱准备时间。
Objective To investigate the effect of water intake on bladder filling time before embryo transfer.MethodsA total of 189 patients were collected from February to June 2023 who were to undergo embryo transfer in Guangdong Women and Children Hospital.The patients were divided into group A(n=61),group B(n=64)and group C(n=64)using a random number table and they were respectively given 300 mL,500 mL and 700 mL water to drink.Abdominal ultrasound was performed every 15 min,a total of 1-5 times,from 45 min after drinking water until the bladder filling.The bladder filling time and bladder volume were collected.Kaplan-Meier method was used to compare the difference of bladder filling time among the three groups.The multivariate Cox regression was used to analyze factors of bladder filling time.Results The cumulative bladder filling rates of group A,group B and group C at 105 min after drinking water were 57.4%(35/61),90.6%(58/64)and 98.4%(63/64),respectively,and the median survival time(95%CI)of bladder filling was 105.0(89.9-120.1)min,60.0(55.4-64.7)min and 60.0(55.4-64.6)min,respectively.Pairwise comparison of Kaplan-Meier analysis revealed that the bladder filling time of group A was longer than that of group B and group C(P<0.001),and there was no statistically significant difference between group B and group C(P>0.05).The results of age-stratification analysis showed that the bladder filling time of younger patients in group A[90.0(75.2-104.8)min]was longer than that in group B[60.0(55.8-64.2)min,P<0.001]and group C[60.0(55.1-64.8)min,P<0.001],and there was no statistical significance between group B and group C(P>0.05);the bladder filling time of older patients in group C[60.0(59.1-70.9)min]was shorter than that in group A[105.0(89.9-120.1)min,P<0.001]and group B[75.0(64.3-85.7)min,P=0.027],there was no statistical significance between group A and group B(P>0.05).Multivariate Cox regression analysis showed that taking group A as reference,the hazard ratio(HR,95%CI)of groups B and C were 2.71(1.78-4.21)and 3.23(2.1
作者
夏美玲
唐纯芳
汪雅琴
罗铭
陈妙虹
钟玲玲
黄莉
张曦倩
翁慧男
张茂玲
Xia Meiling;Tang Chunfang;Wang Yaqin;Luo Ming;Chen Miaohong;Zhong Lingling;Huang Li;Zhang Xiqian;Weng Huinan;Zhang Maoling(Department of Reproductive Health and Infertility,Guangdong Women and Children Hospital,Guangzhou 511400,China)
出处
《中华生殖与避孕杂志》
CAS
CSCD
北大核心
2024年第5期505-509,共5页
Chinese Journal of Reproduction and Contraception
基金
广东省卫济医学发展基金会临床研究项目(K-202104-2)
广州市科技计划项目(202102080503)。
关键词
胚胎移植
生殖技术
辅助
超声
饮水量
膀胱
Embryo transfer
Reproductive techniques,assisted
Ultrasonography
Drinking
Bladder
