摘要
近年来,类器官技术为肿瘤生物学研究、药物筛选、精准医疗和再生医学等领域提供了革命性的技术平台.与传统的二维细胞系和动物模型相比,源自患者的肿瘤类器官模型在结构和功能上更逼真地模拟了人体内的肿瘤微环境和肿瘤异质性,保留了原始肿瘤组织的病理学特征和遗传学信息,成为医学研究人员和临床工作者关注的热点.然而,行业内对于肿瘤类器官的构建及鉴定尚缺乏统一的操作标准,限制了类器官技术在基础研究和临床应用中的广泛推广和应用.因此,为推动类器官技术的规范化和标准化应用,中国抗癌协会联合国内相关领域的专家,制订针对胃癌原发灶和转移灶来源胃癌类器官的培养与质量控制的标准化和可复制的团体标准,旨在为临床工作者和医学研究者提供全面的指导,确保类器官研究的可靠性和可重复性,从而提高研究成果的准确性和应用价值.该团体标准的发布和实施,将为胃癌类器官技术的规范化和广泛应用提供强有力的支持,推动行业的健康、规范发展.随着未来基于胃癌类器官的研究不断深入,该团体标准也将根据最新的研究成果进行定期更新,以持续推动类器官技术在胃癌的基础研究和临床应用中的发展.
Recently,organoid has provided a revolutionary platform for tumor biology research,drug screening,precision medicine,and regenerative medicine.Compared to traditional two-dimensional cell lines and animal models,patient-derived tumor organoid models more accura-tely simulate the tumor microenvironment and tumor heterogeneity within the human body,retai-ning the pathological characteristics and genetic information of the original tumor tissue.This has made them a focal point for medical researchers and clinicians.However,the industry currently lacks unified operational standards for the construction and identification of tumor organoids,limi-ting the widespread promotion and application of organoid technology in basic research and clinical applications.To address this,Chinese Anti-Cancer Association,in collaboration with experts from related fields,has developed a standardized and reproducible group standard for the cultivation and quality control of gastric cancer organoids derived from primary and metastatic lesions.This consensus aims to provide comprehensive guidance for clinicians and medical researchers,ensuring the relia-bility and reproducibility of organoid research,thereby improving the accuracy and application value of research results.The publication and implementation of this group standard will strongly support the standardization and widespread application of gastric cancer organoid technology,promoting the healthy and regulated development of the industry.As research on gastric cancer organoids continues to advance,this group standard will be regularly updated based on the latest research findings,continually promoting the development and application of organoid technology in gastric cancer research and clinical practice.
作者
中国抗癌协会
苗智峰
王振宁
Chinese Anti-Cancer Association;Miao Zhifeng;Wang Zhenning(不详;Department of Gastrointestinal Surgery,The First Afiliated Hospital of China Medical University,Shenyang 110001,China;Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors,Ministry of Education,The First Affiliated Hospital of China Medical University,Shenyang 110001,China)
出处
《中华消化外科杂志》
CAS
CSCD
北大核心
2024年第6期761-769,共9页
Chinese Journal of Digestive Surgery
基金
国家重点研发计划(2022YFA1105300)。
关键词
胃肿瘤
类器官
质量控制
团体标准
Stomach neoplasms
Organoid
Quality control
Group Standard
