摘要
目的:探究骨髓细胞形态学及血清游离轻链(sFLC)、乳酸脱氢酶(LDH)在多发性骨髓瘤(MM)诊断中的应用价值。方法:选择2019年1月至2022年1月新乡市第二人民医院收治的100例确诊MM患者作为研究对象(观察组),另选择80例同期由于其他原因接受骨髓穿刺的受试者作为对照组,测定分析两组患者骨髓浆细胞占比和血清sFLC、LDH水平,并采用受试者工作特征曲线(ROC)分析三种指标对MM的诊断价值。结果:观察组患者骨髓浆细胞占比、血清LDH、sFLC-κ、sFLC-λ水平均高于对照组,差异具有统计学意义(P<0.05);MMⅢ期骨髓浆细胞占比、血清LDH、sFLC-κ、sFLC-λ水平均高于MMⅡ期、MMⅠ期,MMⅡ期骨髓浆细胞占比、血清LDH、sFLC-κ、sFLC-λ水平均高于MMⅠ期,差异均具有统计学意义(P<0.05)。骨髓细胞形态学、血清sFLC、LDH对MM诊断均具有一定价值,且联合诊断具有较高灵敏度和特异度,分别为97.00%和72.00%,曲线下面积(AUC)为0.916(0.311~1.562)。结论:MM患者骨髓浆细胞占比、血清LDH、sFLC-κ、sFLC-λ水平均异常升高,且随患者病情的严重程度而逐步提高,且联合检测MM诊断效能较高。
Objective To investigate the application value of bone marrow cell morphology and serum free light chain(sFLC),lactate dehydrogenase(LDH)in the diagnosis of multiple myeloma(MM).Methods A total of 100 patients with MM diagnosed in Xinxiang Second People's Hospital from January 2019 to January 2022 were selected as the study subjects(observation group),and another 80 subjects who underwent bone marrow aspiration due to other reasons during the same period were selected as the control group.The proportion of bone marrow plasma cells and serum sFLC and LDH levels of the patients in the two groups were determined and analyzed,and the diagnostic value of the three indexes for MM was analyzed by receiver operating characteristic curve(ROC).Results The proportion of bone marrow plasma cells,serum levels of LDH,sFLC-κand sFLC-λin the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).The proportion of bone marrow plasma cells and the levels of serum LDH,sFLC-κand sFLC-λin MM III stage were higher than those in MM II stage,MM I stage,the proportion of bone marrow plasma cells and the levels of serum LDH,sFLC-κand sFLC-λin MM II stage were higher than those in MM I stage,the differences were statistically significant(P<0.05).Bone marrow cell morphology,serum sFLC and LDH had certain value in the diagnosis of MM,and the combined diagnosis had high sensitivity and specificity,which were 97.00%and 72.00%,respectively,and the area under the curve(AUC)was 0.916(0.311-1.562).Conclusion The proportion of bone marrow plasma cells,and the levels of serum LDH,sFLC-κand sFLC-λin MM patients increased abnormally,and gradually increased with the severity of the patient's condition,and the combined detection of MM had higher diagnostic efficiency.
作者
李晓冉
王素玲
许冰
LI Xiaoran;WANG Suling;XU Bing(Xinxiang Second People's Hospital,Henan Xinxiang 453003;Xinxiang First People's Hospital,Henan Xinxiang 453000)
出处
《深圳中西医结合杂志》
2024年第9期63-65,141,共4页
Shenzhen Journal of Integrated Traditional Chinese and Western Medicine
关键词
多发性骨髓瘤
血清游离轻链
乳酸脱氢酶
骨髓浆细胞
Multiple myeloma
Serum free light chain
Lactate dehydrogenase
Bone marrow plasma cell
