摘要
目的:观察疏肝健脾汤联合马来酸曲美布汀胶囊治疗腹泻型肠易激综合征(IBS)的临床疗效。方法:采用随机数字表法将102例腹泻型IBS患者分成对照组、治疗组各51例。对照组给予马来酸曲美布汀胶囊治疗,治疗组在对照组基础上加用疏肝健脾汤治疗,2组均连续治疗4周。比较2组治疗前后中医证候积分及血浆胆囊收缩素(CCK)、酪神经肽(NPY)及P物质(SP)水平;比较2组临床疗效、不良反应发生率及疾病复发率。结果:治疗后,治疗组总有效率为92.16%,高于对照组82.35%(P<0.05)。2组治疗后中医证候积分及血浆CCK、SP水平均低于治疗前(P<0.05),血浆NPY水平高于治疗前(P<0.05);治疗组治疗后中医证候积分及血浆CCK、SP水平低于对照组(P<0.05),血浆NPY水平高于对照组(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。治疗组疾病复发率2.13%,低于对照组9.52%(P<0.05)。结论:疏肝健脾汤联合马来酸曲美布汀胶囊治疗腹泻型IBS疗效确切,能够改善患者胃肠功能,降低疾病复发率,安全性较高。
Objective:To observe the clinical effect of Shugan Jianpi Decoction combined with Trimebutine Maleate Capsules for diarrhea-predominant irritable bowel syndrome(IBS-D).Methods:A total of 102 cases of patients with IBS-D were divided into the control group and the treatment group according to the random number table method,with 51 cases in each group.The control group was treated with Trimebutine Maleate Capsules,and the treatment group was additionally treated with Shugan Jianpi Decoction based on the treatment of the control group.Both groups were continuously treated for four weeks.Traditional Chinese medicine(TCM)syndrome scores,and the levels of plasma cholecystokinin(CCK),neuropeptide Y(NPY),and substance P(SP)were compared between the two groups before and after treatment.The clinical effects,incidence of adverse reactions,and disease recurrence rates were compared between the two groups.Results:After treatment,the total effective rate was 92.16%in the treatment group,higher than that of 82.35%in the control group(P<0.05).After treatment,TCM syndrome scores and the levels of plasma CCK and SP in the two groups were lower than those before treatment(P<0.05),and the levels of plasma NPY were higher than those before treatment(P<0.05);TCM syndrome scores and the levels of plasma CCK and SP in the treatment group were lower than those in the control group(P<0.05),the level of plasma NPY in the treatment group was higher than that in the control group(P<0.05).There was no significant difference being found in the comparison of the incidence of adverse reactions between the two groups(P>0.05).The disease recurrence rate was 2.13%in the treatment group,lower than that of 9.52%in the control group(P<0.05).Conclusion:Shugan Jianpi Decoction combined with Trimebutine Maleate Capsules has a definite cureative effect in the treatment of IBS-D,which can improve gastrointestinal function and reduce disease recurrence rate,with high safety.
作者
翁伟安
李慧辉
WENG Wei'an;LI Huihui(Department of Chinese Medicine,The Third Affiliated Hospital of Wenzhou Medical University,Wenzhou Zhejiang 325200,China;Department of Orthopedics of Chinese Medicine,The Third Affiliated Hospital of Wenzhou Medical University,Wenzhou Zhejiang 325200,China)
出处
《新中医》
CAS
2024年第11期54-57,共4页
New Chinese Medicine
基金
温州市科研项目(Y2020891)。
关键词
肠易激综合征
腹泻型
疏肝健脾汤
马来酸曲美布汀胶囊
胆囊收缩素
酪神经肽
P物质
Irritable bowel syndrome
Diarrhea-predominant type
Shugan Jianpi Decoction
Trimebutine Maleate Capsules
Cholecystokinin
Neuropeptide Y
Substance P
