摘要
目的 探讨老年内科住院病人血清脂蛋白(a)[Lp(a)]水平与静脉血栓栓塞症(VTE)风险的相关性。方法 收集2021年1—6月就诊于河北省人民医院老年内科的病人246例,根据Padua评分分为VTE风险低危组(<4分),VTE风险高危组(≥4分)。收集2组的临床资料,并对比2组病人Lp(a)水平的差异。应用Spearman相关分析研究Lp(a)和Padua评分的相关性,应用多因素Logistic回归分析老年内科住院病人VTE高风险的相关因素,并进一步利用ROC曲线分析Lp(a)对VTE风险的预测价值。结果 VTE风险高危组的年龄及Lp(a)、D-二聚体(D-D)水平明显高于低危组(P<0.01);Lp(a)水平与Padua评分、D-D均呈正相关(r分别为0.427、0.225,均P<0.01)。多因素Logistic回归分析表明,Lp(a)、D-D、年龄均与老年内科住院病人VTE风险密切相关(均P<0.01)。ROC曲线分析显示,Lp(a)评估老年内科住院病人VTE高风险的AUC为0.742,截断值为268.5 mg/L,敏感度为66.0%,特异度为76.0%。结论 Lp(a)水平与老年内科住院病人VTE风险明显相关。
Objective To investigate the correlation between the level of lipoprotein(a)[Lp(a)]and the risk of venous thrombus embolism(VTE)in the elderly inpatients.Methods A total of 246 patients admitted to Department of Geriatrics of Hebei General Hospital from January to June 2021 were divided into low-risk VTE group(<4 points)and high-risk VTE group(≥4 points)according to Padua score.The clinical data and the level of Lp(a)were collected and compared between the two groups.Spearman correlation analysis was used to analyze the correlation between Lp(a)and Padua score.Multivariate Logistic regression analysis was used to analyze the influencing factors for the risk of VTE in the elderly inpatients.The predictive value of Lp(a)for VTE was analyzed by receiver operating characteristic(ROC)curve.Results The levels of age,Lp(a)and D-dimer(D-D)in the high-risk VTE group were significantly higher than those in the low-risk group(P<0.01).The level of Lp(a)was positively correlated with Padua score and D-D(r=0.427,0.225;P<0.01).Multivariate Logistic regression analysis showed that Lp(a),D-D and age were the risk factors for VTE in the elderly inpatients(P<0.01).ROC curve showed that the area under curve(AUC)of Lp(A)to evaluate the high risk of VTE was 0.742,with the cut-off value of 268.5 mg/L,the sensitivity of 66.0%,and the specificity of 76.0%.Conclusions Lp(a)level is significantly correlated with the risk of VTE in the elderly inpatients.
作者
孔超敏
吕彩霞
姚丽霞
苑晓烨
王素星
邵伟华
白雪冬
吴思思
杨爽
李芳
KONG Chaomin;LYV Caixia;YAO Lixia;YUAN Xiaoye;WANG Suxing;SHAO Weihua;BAI Xuedong;WU Sisi;YANG Shuang;LI Fang(Department of Geriatric Cardiology,Hebei General Hospital,Shijiazhuang 050051,China)
出处
《实用老年医学》
CAS
2024年第7期705-708,共4页
Practical Geriatrics
基金
国家自然科学基金青年科学基金资助项目(81600072)
河北省自然科学基金青年科学基金资助项目(H2016307015)
河北省医学科学研究重点课题计划(20220871)
河北省政府资助临床医学项目(ZF2023202)。
