摘要
目的 分析德谷门冬双胰岛素、基础-餐时胰岛素短期强化治疗对新诊断2型糖尿病(T2DM)患者血糖控制的影响。方法 选取60例新诊断T2DM患者为研究对象,依据随机数字法分为对照组(30例,德谷门冬双胰岛素治疗)、研究组(30例,基础-餐时胰岛素短期强化治疗)。对比两组患者的血糖指标[糖化血红蛋白(HbA1c)、空腹血糖(FPG)和餐后2 h血糖(2 h PBG)],血糖控制情况(血糖达标时间、血糖波动水平)和低血糖发生率,治疗效果。结果 两组治疗前HbA1c、FPG和2 h PBG水平对比无显著差异(P>0.05);治疗后,研究组HbA1c(6.08±0.76)%、FPG(5.71±0.59)mmol/L和2 h PBG(7.53±0.96)mmol/L比对照组的(8.19±1.14)%、(6.86±0.84)mmol/L、(9.38±1.33)mmol/L低,差异具有统计学意义(P<0.05)。研究组患者血糖达标时间为(6.95±1.61)d、血糖波动为(2.25±0.35)mmol/L、夜间低血糖发生率为0;对照组患者血糖达标时间为(8.26±1.56)d、血糖波动为(3.12±0.68)mmol/L、夜间低血糖发生率为20.00%;研究组患者的血糖达标时间、血糖波动水平和低血糖发生率均显著低于对照组,差异具有统计学意义(P<0.05)。研究组患者的治疗总有效率(100.00%)显著高于对照组(80.00%),差异具有统计学意义(P<0.05)。结论 对于新诊断T2DM患者来说,基础-餐时胰岛素短期强化治疗相对于德谷门冬双胰岛素疗效较好,值得推广。
Objective To analyze the effect of insulin degludec/insulin aspart and basal-prandial insulin short-term intensive therapy on glycemic control of newly diagnosed type 2 diabetes mellitus(T2DM).Methods 60 patients with newly diagnosed type 2 diabetes were selected as the research subjects.They were divided into the control group(30 cases,insulin degludec/insulin aspart)and the study group(30 cases,short-term intensive treatment with basal-prandial insulin)according to random numerical table.Both groups were compared in terms of blood glucose index[glycosylated hemoglobin(HbA1c),fasting plasma glucose(FPG)and 2 h postprandial blood glucose(2 h PBG)],blood glucose control(time for reaching blood glucose standards,blood glucose fluctuation level),incidence of hypoglycemia and therapeutic effect.Results Before treatment,there were no significant differences in levels of HbA1c,FPG and 2 h PBG between the two groups(P>0.05).After treatment,the study group had HbA1c of(6.08±0.76)%,FPG of(5.71±0.59)mmol/L and 2 h PBG of(7.53±0.96)mmol/L,which were lower than(8.19±1.14)%,(6.86±0.84)mmol/L and(9.38±1.33)mmol/L in the control group,and the difference was statistically significant(P<0.05).In the study group,the time for reaching blood glucose standards was(6.95±1.61)d,the blood glucose fluctuation was(2.25±0.35)mmol/L,and the incidence of nocturnal hypoglycemia was 0.In the control group,the time for reaching blood glucose standards was(8.26±1.56)d,the blood glucose fluctuation was(3.12±0.68)mmol/L,and the incidence of nocturnal hypoglycemia was 20.00%.The time for reaching blood glucose standards,blood glucose fluctuation level and incidence of hypoglycemia in the study group were significantly lower than those in the control group,and the difference was statistically significant(P<0.05).The total effective rate of the study group(100.00%)was significantly higher than that of the control group(80.00%),and the difference was statistically significant(P<0.05).Conclusion For newly diagnosed type 2 diabetes mellitus pa
作者
王咏梅
WANG Yong-mei(Dezhou Hospital of Integrated Traditional Chinese and Western Medicine(Dezhou Anorectal Hospital),Dezhou 253016,China)
出处
《中国实用医药》
2024年第12期121-124,共4页
China Practical Medicine
关键词
2型糖尿病
德谷门冬双胰岛素
基础-餐时胰岛素
短期强化治疗
血糖
Type 2 diabetes mellitus
Insulin degludec/insulin aspart
Basal-prandial insulin
Short-term intensive therapy
Blood glucose
