摘要
目的探讨老年2型糖尿病(T2DM)患者中医证型与临床指标的关系。方法收集2020年1月—2022年1月于河南中医药大学第一附属医院内分泌科住院的446例老年T2DM患者的病例资料,统计患者中医证型分布情况,分析中医证型与性别、年龄、病程、体质指数(BMI)、踝肱指数(ABI)、空腹血糖(FPG)、餐后2 h血糖(2hPG)、糖化血红蛋白(HbA1c)、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、尿微量白蛋白(UMA)、尿微量白蛋白/肌酐比值(UACR)的关系,对有统计学意义的指标进行多因素Logistic回归分析。结果老年T2DM患者中医证型占比由高到低依次为气阴两虚证、湿热内蕴证、脾虚痰湿证、肝肾阴虚证、脾肾阳虚证。不同中医证型患者性别、年龄、病程、BMI、ABI分布情况、2hPG、HDL-C、UMA、UACR比较差异均有统计学意义(P均<0.05),FPG、HbA1c、TC、TG、LDL-C比较差异均无统计学意义(P均>0.05)。多因素Logistic回归分析显示,脾虚痰湿证、气阴两虚证与年龄呈正相关,湿热内蕴证与年龄呈负相关;湿热内蕴证与性别呈正相关,脾虚痰湿证、气阴两虚证与性别呈负相关;脾肾阳虚证与病程呈正相关,脾虚痰湿证、湿热内蕴证、气阴两虚证、肝肾阴虚证与病程呈负相关;脾虚痰湿证、肝肾阴虚证、脾肾阳虚证与BMI呈正相关,气阴两虚证与BMI呈负相关;脾肾阳虚证与ABI呈正相关;湿热内蕴证、气阴两虚证与2hPG呈正相关,脾虚痰湿证与2hPG正负相关;脾虚痰湿证、湿热内蕴证、气阴两虚证、肝肾阴虚证与HDL-C呈正相关,脾肾阳虚证与HDL-C呈负相关;脾肾阳虚证与UACR呈正相关,脾虚痰湿证、湿热内蕴证、气阴两虚证与UACR呈负相关。结论气阴两虚证为老年T2DM的主要证型;老年T2DM患者的中医证型与性别、年龄、病程、BMI、ABI分布情况、2hPG、HDL-C、UACR存在相关性,其中性别、年龄、病�
Objective It is to explore the relationship between Chinese medicine syndrome types and clinical indicators in elderly patients with type 2 diabetes mellitus(T2DM).Methods The case data of 446 elderly T2DM patients hospitalized in the Department of Endocrinology of the First Affiliated Hospital of Henan University of Chinese Medicine from January 2020 to January 2022 were collected,and the distribution of patients’Chinese medicine syndromes was counted to analyze the correlations of Chinese medicine syndromes with gender,age,duration of disease,body mass index(BMI),ankle-brachial index(ABI),fasting plsama glucose(FPG),2 h postprandial glucose(2hPG),glycosylated hemoglobin(HbA1c),total cholesterol(TC),triacylglycerol(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),urinary microalbumin(UMA),and urinary microalbumin/creatinine ratio(UACR),and the statistically significant indexes were analyzed by multifactor Logistic analysis.Results The proportions of Chinese medicine syndrome types in elderly T2DM patients from high to low were as follows:syndrome of Qi-Yin deficiency,syndrome of damp-heat interaccumulation,syndrome of spleen deficiency and phlegm-dampness,syndrome of liver-kidney Yin deficiency,and syndrome of spleen-kidney Yang deficiency.There were significant differences in gender,age,disease duration,BMI,ABI distribution,2hPG,HDL-C,UMA and UACR among patients with different syndromes(all P<0.05),and no significant differences in FPG,HbA1c,TC,TG and LDL-C(all P>0.05).Multifactorial Logistic regression analysis showed that syndrome of Qi-Yin deficiency,syndrome of spleen deficiency and phlegm-dampness were positively correlated with age,syndrome of damp-heat interaccumulation was positively correlated with age;syndrome of damp-heat interaccumulation was negatively correlated with gender,syndrome of Qi-Yin deficiency,syndrome of spleen deficiency and phlegm-dampness were negatively correlated with gender;syndrome of spleen-kidney Yang deficiency was positively correla
作者
葛金华
冯志海
GE Jinhua;FENG Zhihai(The First Clinical Medical College of Henan University of Chinese Medicine,Zhengzhou 450046,Henan,China;The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,Henan,China)
出处
《现代中西医结合杂志》
CAS
2024年第11期1508-1514,共7页
Modern Journal of Integrated Traditional Chinese and Western Medicine
基金
河南省首批青苗人才培养项目[豫中医科教(2018)16号]。
关键词
老年2型糖尿病
中医证型
临床指标
相关性
elderly type 2 diabetes mellitus
Chinese medicine syndrome
clinical indicator
correlation
