摘要
目的分析湖南省女性人乳头瘤病毒(HPV)感染情况以及HPV亚型与宫颈上皮细胞和组织病理改变的关系,为当地HPV流行病学提供数据支持。方法采集2020-2022年湖南省326824名参加宫颈癌筛查和健康体检人群的宫颈脱落上皮细胞,采用荧光PCR技术检测其HPV分型,统计分析不同年龄、地区各HPV分型感染状况;其中9940例进行液基薄层细胞学检查(TCT)检查或病理学检查,分析其HPV感染情况与细胞病理学阳性结局的关系。结果HPV总体感染率为10.9%(35646/326824),其中单一型感染占81.9%(29201/35646),多重型感染占18.1%(6445/35646);单一型占比前6位型别依次为HPV52(20.5%)、HPV58(16.0%)、HPV16(12.9%)、HPV53(11.9%)、HPV81(8.7%)和HPV70(8.6%)。≥60岁组感染率最高,为15.7%(3672/23315),HPV感染阳性人群中,不同年龄组多重型感染占比总体差异有统计学意义,χ^(2)=365.910,P<0.001。按病例来源划分,感染率最高的地区为张家界市〔13.1%(2089/15982)〕,最低的地区为永州市〔8.7%(3219/37058)〕。单一型感染者组织和细胞学阳性率为47.1%(3618/7683),多重型感染者阳性率为58.8%(1326/2257),χ^(2)=94.867,P<0.001。在7683例单一型HPV感染者中,HPV39、HPV66、HPV16、HPV6、HPV33、HPV42、HPV59和HPV58组织和细胞学阳性率均超过50%。结论≥60岁人群HPV感染率最高,应加强对这一人群HPV感染的防治力度;HPV52和HPV58是全部人群中最为常见的型别;多重型HPV感染更可能导致宫颈疾病的发生。
Objective To analyze the infection status of human papillomavirus(HPV)in women in Hunan Province,as well as the relationship between HPV subtypes and pathological changes in cervical epithelial cells and tissues,to provide data support for local HPV epidemiology.Methods A total of 326824 cervical epithelial cells from the population participating in cervical cancer screening and health examinations in Hunan Province from 2020 to 2022 were collected.Using fluorescence PCR technology to detect their HPV typing,and statistically analyze the HPV infection status of different age groups and regions;Among them,9940 cases underwent thin-prep cytology test or pathological examination to analyze the relationship between their HPV infection status and positive results in cell pathology.Results The overall infection rate of HPV was 10.9%(35646/326824),with monotypic infection accounting for 81.9%(29201/35646)and multi severe infection accounting for 18.1%(6445/35646);The top 6 types with a single type proportion were HPV52(20.5%),HPV58(16.0%),HPV16(12.9%),HPV53(11.9%),HPV81(8.7%),and HPV70(8.6%).The infection rate in the≥60 years old group was the highest[15.7%(3672/23315)].Among the HPV positive population,there was a statistically significant difference in the proportion of multiple severe infections among different age groups,χ^(2)=365.910,P<0.001.According to the source of cases,the highest infection rate was 13.1%(2089/15982)in Zhangjiajie City,and the lowest was 8.7%(3219/37058)in Yongzhou City.The positive rate of tissue and cytology in single type infections was 47.1%(3618/7683),while the positive rate in multiple severe infections was 58.8%(1326/2257),χ^(2)=94.867,P<0.001.Among 7683 cases of single type HPV infection,the positive rates of HPV39,HPV66,HPV16,HPV6,HPV33,HPV42,HPV59 and HPV58 in tissue and cytology were exceeded 50%.Conclusions HPV infection rate among people over 60 years old is the highest,and efforts should be strengthened to prevent and control HPV infection in this population.HPV52 and HPV58 a
作者
陈少强
吴颖
谢艳
郭俊龙
李菁
谢小兵
李萍
CHEN Shaoqiang;WU Ying;XIE Yan;GUO Junlong;LI Jing;XIE Xiaobing;LI Ping(Medical Laboratory and Pathology Center,First Hospital of Hunan University of Chinese Medicine,Changsha,Hunan 410007,China;PCR Room,Changsha Dean Medical Laboratory Co.,Ltd.,Changsha,Hunan 41ooo7,China)
出处
《中华肿瘤防治杂志》
CAS
北大核心
2024年第7期399-404,共6页
Chinese Journal of Cancer Prevention and Treatment
基金
湖南省自然科学基金(2022JJ30455)
湖南省临床医疗技术创新引导项目(2021SK51409)
湖南省科技厅重点领域研发计划(2022GK2057)。
关键词
人乳头瘤病毒
感染率
宫颈肿瘤
宫颈上皮内瘤样病变
湖南省
human papillomavirus
infection rate
cervical tumors
cervical intraepithelial neoplasia
Hunan Province
