摘要
为探究不同力学性能皮肤对无针注射效果的影响,通过注射不同质量分数的凝胶皮肤模型进行注射效果分析。首先,通过自制压力测试平台,分析不同注射参数下气动式无针注射系统微射流动力学特征;其次,采用气动式无针注射系统分别开展凝胶注射试验与离体猪肉组织注射试验,探究凝胶注射试验的可靠性;在此基础上,分别开展单层、双层及多层凝胶注射试验,探究多层结构组织及不同层间界面条件下气动式无针注射系统微射流的扩散特征。研究结果表明:随着凝胶弹性模量增大,注射深度、扩散面积和注射完成率均减小;同时,分界面一定条件下起到促进药液横向扩散作用,疏松界面一定会出现层间积液,紧密界面可能出现层间漏液现象。研究结果可为无针注射系统在不同力学性能皮肤条件下的进一步发展应用提供理论依据和技术支撑。
Here,to explore influences of skins with different mechanical properties on the needle-free injection effect,the injection effect was analyzed by using gel skin model injected with different mass fractions.Firstly,by using a self-made pressure testing platform,micro-jet dynamic characteristics of a pneumatic needle-free injection system under different injection parameters were analyzed.Secondly,the pneumatic needle-free injection system was used to perform gel injection tests and isolated pork tissue injection tests,respectively,and explore the reliability of gel injection tests.Afterwards,single-layer,double-layer and multi-layer gel injection tests were conducted to explore diffusion characteristics of micro jet in pneumatic needle-free injection system under conditions of multi-layer structure tissue and different interlayer interfaces.The results showed that injection depth,diffusion area and injection completion rate decrease with increase in gel Young’s modulus;meanwhile,under certain conditions,interface plays a role in promoting lateral diffusion of drug solution;loose interfaces can inevitably cause interlayer liquid accumulation,while tight interfaces may have interlayer liquid leakage;the study results can provide theoretical basis and technical support for further development and application of needle-free injection system under conditions of skin with different mechanical performances.
作者
李佳敏
曾栋坪
康勇
LI Jiamin;ZENG Dongping;KANG Yong(School of Power and Mechanical Engineering,Wuhan University,Wuhan 430072,China;College of Energy and Power Engineering,Changsha University of Science and Technology,Changsha 410114,China)
出处
《振动与冲击》
EI
CSCD
北大核心
2024年第13期153-161,209,共10页
Journal of Vibration and Shock
基金
湖南省自然科学基金(2023JJ40030)。
关键词
水射流技术
射流冲击特征
弹性模量
皮肤厚度
射流扩散特征
water jet technology
jet impact characteristics
elastic modulus
skin thickness,jet diffusion characteristics
