摘要
青少年抑郁症患者相较于成年抑郁症患者,具有更高的发病率、较差的生活质量和治疗效果。国际指南普遍推荐轻度青少年抑郁症优先考虑心理治疗,对于中重度患者,抗抑郁药物联合心理治疗是1种可行的选择,如何选择适合的抗抑郁药物仍然是待解决的难题。抗抑郁药物存在一系列副作用,包括睡眠障碍、锥体外系反应和消化道反应等,为了减轻这些副作用并提高临床疗效,个体化的治疗方案至关重要。总结了青少年抑郁症的发病机制、抗抑郁药物的药代动力学和副作用,以及2013~2023年针对青少年抑郁症患者的用药指南,并针对青少年抑郁症患者药物治疗方案提出科学建议。
Compared with adult patients with depression,adolescents with depression have a higher incidence rate,poorer quality of life and poorer treatment effects.International guidelines generally recommend giving priority to psychological treatment for mild adolescent depression.For moderate to severe patients,antidepressant drugs combined with psychotherapy are a feasible option.How to choose suitable antidepressant drugs is still a problem to be solved.Antidepressant drugs have a series of side effects,including sleep disorders,extrapyramidal reactions,and gastrointestinal reactions.In order to reduce these side effects and improve clinical efficacy,individualized treatment plans are crucial.This article summarizes the pathogenesis of adolescent depression,the pharmacokinetics and side effects of antidepressant drugs,as well as the medication guidelines for adolescent patients with depression from 2013 to 2023,and provides scientific suggestions for drug treatment options for adolescent patients with depression.
作者
行浩然
张曦
张盈盈
鲍天昊
XING Haoran;ZHANG Xi;ZHANG Yingying;BAO Tianhao(The Mental Health Center Affiliated to Kunming Medical University/Science and Education Department,The Mental Hospital of Yunnan,Kunming Yunnan 650224,China)
出处
《昆明医科大学学报》
CAS
2024年第7期168-176,共9页
Journal of Kunming Medical University
基金
国家自然科学基金资助项目(82160269,82160272)
云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目(202101AY070001-033,202201AY070001-212)
云南省教育厅科学研究基金研究生项目(2024Y248)
“春城计划”高层次人才培养计划春城拔尖人才专项(C201914016)
昆明医科大学研究生创新基金资助项目(2024S136)。
关键词
青少年
抑郁症
抗抑郁药物
药代动力学
疗效
副作用
Adolescent
Depression
Antidepressive agents
Pharmacokinetics
Efficacy
Side effects
