摘要
普雷沃氏菌(Prevotella)是短杆状的厌氧性革兰氏阴性菌,属于普氏菌科普雷沃氏菌属。Prevotella在饮食以植物为主的非西方人群中显示出较高的存在率,而Prevotella copri(P.copri)是该菌属中丰度最高的细菌。P.copri可以直接或间接驱动炎症反应,从而促进炎症相关疾病的发生。研究发现,P.copri通过激活TLR4和mTOR通路、产生琥珀酸盐等途径促进炎症性肠病的发生发展;另外,P.copri可以诱导机体产生抗体、刺激Th17和Th1反应、产生琥珀酸盐、介导瓜氨酸化以触发免疫反应,从而促进类风湿性关节炎的发生发展;P.copri可通过影响支链氨基酸的生物合成诱导胰岛素抵抗,可能导致2型糖尿病,相反,动物实验研究表明,P.copri可以通过胆汁酸代谢、FXR通路等途径改善葡萄糖稳态。本文旨在探讨肠道P.copri与人类炎症相关疾病之间的关系,以增进对P.copri功能和特性的理解,并为未来的研究提供参考。
Prevotellais a short rod-shaped anaerobic Gram negative bacterium,belonging to the family Prevotellaand the genus Prevotella.Prevotellagenus has been found to have a higher prevalence in non-western populations with a plant-based diet,and Prevotellacopri(P.copri)is the most abundant bacterium in this genus.P.coprihas the potential to directly or indirectly drives inflammatory response,thereby promoting the occurrence of inflammation-related diseases.Researches have found that P.copri promotes the occurrence and development of inflammatory bowel disease through pathways such as activating TLR4 and mTOR pathways and producing succinate.Furthermore,P.copri can induce the production of antibodies,stimulate Th17 and Th1 responses,produce succinate,mediate guanylation to trigger immune reactions,thereby promoting the occurrence and development of rheumatoid arthritis.P.copri can induce insulin resistance by affecting the biosynthesis of branched-chain amino acids,potentially leading to type 2 diabetes.Conversely,animal experiments have shown that P.coprican improve glucose homeostasis through pathways such as intestinal gluconeogenesis,bile acid metabolism,and the FXR pathway.This article aims to explore the relationship between intestinal P.copriand human inflammatory diseases,trying to enhance understanding of the functions and characteristics of P.copri,and to provide reference for future research.
作者
陈玲霞
谢冰玉
宋涛
刘志平
CHEN Ling-xia;XIE Bing-yu;SONG Tao;LIU Zhi-ping(School of Basic Medicine,Gannan Medical University,Ganzhou,Jiangxi 341000)
出处
《赣南医学院学报》
2024年第6期565-570,共6页
JOURNAL OF GANNAN MEDICAL UNIVERSITY
基金
国家自然科学基金项目(31960163)
江西省教育厅科学技术研究项目(GJJ201507,GJJ180802)
江西省卫生健康委员会科技计划项目(SKJP220210670)
江西省林业局油茶研究专项项目(YCYJZX2023312)。
