摘要
肝移植术后排斥反应严重影响受者生存,长期应用免疫抑制药是预防排斥反应的重要手段,但其存在毒性作用,以及会增加全身感染、肿瘤复发等不良事件的风险。因此,在成功肝移植手术之前,如何对受者实施个体化免疫耐受诱导,实现术后免疫抑制药完全或早期撤退,仍然是器官移植工作者不断探索的研究方向。近年来,耐受性树突状细胞诱导肝移植免疫耐受的机制研究取得了一些新的进展,临床试验初显成效。本文就耐受性树突状细胞的特征、参与重塑肝脏免疫微环境的机制及其诱导肝移植免疫耐受基础研究与临床应用进展进行综述,以期为耐受性树突状细胞在肝移植免疫耐受中的应用研究提供参考。
Rejection after liver transplantation severely affects the survival of recipients.Long-term use of immunosuppressants is an important approach to prevent rejection,whereas it may cause toxic effects and increase the risk of adverse events such as systemic infection and tumor recurrence,etc.Therefore,before successful liver transplantation,how to induce individual immune tolerance of recipients and achieve complete or early withdrawal of postoperative immunosuppressants remains to be investigated by practitioners of organ transplantation.In recent years,certain progresses have been made in the mechanism of immune tolerance induced by tolerogenic dendritic cells in liver transplantation,and preliminary outcomes have been obtained in clinical trials.In this article,basic research and clinical application progress in the characteristics of tolerogenic dendritic cells,the mechanism underlying participating in liver immune microenvironment remodeling,and inducing immune tolerance in liver transplantation were reviewed,aiming to provide reference for the application of tolerogenic dendritic cells in immune tolerance of liver transplantation.
作者
杨志琦
李明皓
Yang Zhiqi;Li Minghao(The Third Clinical Medical College of Ningxia Medical University,Yinchuan 750002,China)
出处
《器官移植》
CAS
CSCD
北大核心
2024年第4期575-580,共6页
Organ Transplantation
基金
宁夏自然科学基金(2021AAC03308)
宁夏回族自治区人民医院科技创新人才项目(院党发〔2023〕72号)
宁夏回族自治区人民医院国家自然科学基金预实验项目(2024GZRYSY0015)。
关键词
树突状细胞
肝移植
免疫耐受
排斥反应
免疫抑制药
细胞因子
共刺激分子
交叉修饰
免疫微环境
Dendritic cell
Liver transplantation
Immune tolerance
Rejection
Immunosuppressant
Cytokine
Costimulatory molecule
Cross modification
Immune microenvironment
