摘要
结直肠癌(CRC)在全球的发病率逐年上升,是全球最常见的消化道恶性肿瘤之一。CD8^(+)T细胞是CRC肿瘤免疫中的主要效应细胞,也是免疫治疗主要靶细胞,对CRC患者的治疗和预后具有重要影响。但由于肿瘤微环境中各种细胞、细胞因子、代谢产物的抑制作用,CD8^(+)T细胞常常处于功能失活状态。因此,了解CD8^(+)T细胞与CRC肿瘤微环境中的相互作用对研发更加有效的治疗策略十分必要。文章就此领域的研究进展做一综述。
The incidence of colorectal cancer(CRC)is steadily increasing worldwide and has now emerged as the most prevalent gastrointestinal malignancy globally.CD8^(+)T cells play a pivotal role in tumor immunity against CRC and serve as the primary target for immunotherapy,thereby exerting a significant impact on treatment outcomes and patient prognosis.However,due to the inhibitory effects imposed by various cellular components,cytokines,and metabolites within the tumor microenvironment,CD8^(+)T cells often experience functional inactivation.Therefore,comprehending the intricate interactions between CD8^(+)T cells and the colorectal tumor microenvironment is imperative for devising more efficacious therapeutic strategies.This review paper provides an overview of recent advancements in this field.
作者
刘天宇
陆晨
鄂一民
喻春钊
LIU Tianyu;LU Chen;E Yimin;YU Chunzhao(Department of General Surgery,Sir Run Run Hospital of Nanjing Medical University,Nanjing 211112,China;Department of General Surgery,the Second Affiliated Hospital of Nanjing Medical University,Nanjing 210011,China)
出处
《中国肿瘤外科杂志》
CAS
2024年第3期288-295,共8页
Chinese Journal of Surgical Oncology
基金
国家自然科学基金面上项目(82373293)
江苏省“333工程”培养资金(BRA2020091)
江苏省卫生健康委科研项目(ZD2022063)。
