摘要
多器官功能障碍综合征(MODS)常常会导致炎症反应失控、能量代谢障碍以及多器官交互作用紊乱,是患者疾病后期高病死率的主要原因。器官交互作用是指通过细胞、可溶性物质或神经激素途径介导的器官之间的复杂生物通信。目前,已有大量研究证据表明心脏与肠道菌群、肺、肾、肝和大脑等多个组织器官之间存在密切且复杂的交互作用。本文对MODS的发病机制,器官交互紊乱的病理生理基础以及心脏与肠道、肝脏和大脑等重要器官之间的交互作用和调控机制进行综述,不仅有助于早期预测和干预与MODS发生发展相关的风险因素,还将为MODS的治疗提供新的干预靶点。
Multiple organ dysfunction syndrome(MODS)often leads to uncontrolled inflammatory response,energy metabolism disorders and multi-organ interaction disorder,which is the main cause of high mortality in patients in the later stages of the disease.Organ interaction refers to the complex biological communication between organs mediated by cells,soluble substance or neurohormone pathways.At present,there is a lot of research evidence indicating close and complex interactions between the heart and intestinal flora,lung,kidney,liver and brain.In this paper,we reviewed the pathogenesis of MODS,the pathophysiological basis of organ interaction disorder,and the interaction and regulation mechanism between heart and intestine,liver and brain,which will not only help to predict and intervene the risk factors related to the occurrence and development of MODS in the early stage,but also provide new intervention targets for the treatment of MODS.
作者
闫浩杰
邵钧捷
周晶晶
岳帅
蒋敏
张然
Yan Haojie;Shao Junjie;Zhou Jingjing;Yue Shuai;Jiang Min;Zhang Ran(Department of Cardiology,Sixth Medical Center,Chinese PLA General Hospital,Beijing 100142,China;Graduate School,Chinese PLA General Hospital,Beijing 100853,China;Section of Respiratory and Critical Care Medicine,Eighth Medical Center,Chinese PLA General Hospital,Beijing 100091,China;National Key Laboratory of Kidney Diseases,Chinese PLA General Hospital,Beijing 100853,China)
出处
《中华老年多器官疾病杂志》
2024年第6期472-476,共5页
Chinese Journal of Multiple Organ Diseases in the Elderly
基金
科技部重点研发计划(2021YFC2701700,2021YFC2701703)。
关键词
多器官功能障碍综合征
心脏
器官交互
multiple organ dysfunction syndrome
heart
organ crosstalk
